Decreased myelin-related gene expression in the nucleus accumbens during spontaneous neonatal opioid withdrawal in the absence of long-term behavioral effects …

KN Borrelli, KK Wingfield, EJ Yao, CA Zamorano… - …, 2023 - Elsevier
Prenatal opioid exposure is a major health concern in the United States, with the incidence
of neonatal opioid withdrawal syndrome (NOWS) escalating in recent years. NOWS occurs …

Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice

KN Borrelli, EJ Yao, WW Yen, RA Phadke, QT Ruan… - ENeuro, 2021 - eneuro.org
The opioid epidemic led to an increase in the number of neonatal opioid withdrawal
syndrome (NOWS) cases in infants born to opioid-dependent mothers. Hallmark features of …

[HTML][HTML] Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

AD Dunn, SA Robinson, C Nwokafor, M Estill… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Infants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid
Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including …

Neonatal Opioid Withdrawal Syndrome in Mice: Acute Molecular and Long‐Term Behavioral Consequences

JR Ferrante, AD Dunn, J Mengaziol… - The FASEB …, 2022 - Wiley Online Library
Populations affected by the ongoing opioid epidemic include pregnant women and their
offspring. Infants exposed to opioids in utero are at risk of developing Neonatal Opioid …

Differences in withdrawal symptoms, microglia activity, and cognitive functioning in rats exposed to continuous low-dose heroin in-utero

SL Mills-Huffnagle, CN Zawatsky, G Bryant… - Neurotoxicology and …, 2024 - Elsevier
Introduction Opioid use during pregnancy and subsequent neonatal opioid withdrawal
syndrome (NOWS) have been associated with poor developmental outcomes including …

[HTML][HTML] Opioid withdrawal behavior in spiny mice: A novel preclinical model of neonatal opioid withdrawal syndrome (NOWS)

S Stevens, S Mohan - Heliyon, 2021 - cell.com
As the opioid epidemic continues to grow, opioid use among pregnant women is increasing
significantly. This has led to a steady rise in the number of infants born with neonatal opioid …

Perinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice

E Minakova, MO Mikati, MK Madasu, SM Conway… - …, 2022 - Springer
Rationale In utero opioid exposure is associated with lower weight and a neonatal opioid
withdrawal syndrome (NOWS) at birth, along with longer-term adverse neurodevelopmental …

[HTML][HTML] Perigestational Opioid Exposure Alters Alcohol-Driven Reward Behaviors in Adolescent Rats

CT Searles, HJ Harder, ME Vogt, AZ Murphy - bioRxiv, 2023 - ncbi.nlm.nih.gov
Every fifteen minutes, a baby is born in the US experiencing neonatal opioid withdrawal
syndrome (NOWS). Since 2004, the rate of NOWS has increased 7-fold. Clinical studies …

Developmental opioid exposures: neurobiological underpinnings, behavioral impacts, and policy implications

SS Goldfarb, GD Stanwood, HA Flynn… - Experimental …, 2020 - journals.sagepub.com
The devastating impact of opioid abuse and dependence on the individual, family, and
society are well known but extremely difficult to combat. During pregnancy, opioid drugs and …

[HTML][HTML] Advances in animal models of prenatal opioid exposure

JR Ferrante, JA Blendy - Trends in Neurosciences, 2024 - cell.com
Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The
complexity of in utero opioid exposure in clinical studies makes it difficult to investigate …