Equivalence of plasma p‐tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease

J Therriault, S Servaes, C Tissot… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma biomarkers are promising tools for Alzheimer's disease (AD)
diagnosis, but comparisons with more established biomarkers are needed. METHODS We …

[HTML][HTML] Comparison of two plasma p-tau217 assays to detect and monitor Alzheimer's pathology

J Therriault, NJ Ashton, I Pola, G Triana-Baltzer… - …, 2024 - thelancet.com
Background Blood-based biomarkers of Alzheimer's disease (AD) have become
increasingly important as scalable tools for diagnosis and determining clinical trial eligibility …

Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

S De Meyer, J Vanbrabant… - Annals of clinical …, 2022 - Wiley Online Library
Abstract Objective Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical
Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is …

Plasma biomarkers of Alzheimer's disease: a review of available assays, recent developments, and implications for clinical practice

MV Pais, OV Forlenza, BS Diniz - Journal of Alzheimer's …, 2023 - content.iospress.com
Recently, low-sensitive plasma assays have been replaced by new ultra-sensitive assays
such as single molecule enzyme-linked immunosorbent assay (Simoa), the Mesoscale …

Head‐to‐head comparison of clinical performance of CSF phospho‐tau T181 and T217 biomarkers for Alzheimer's disease diagnosis

TK Karikari, A Emeršič, A Vrillon… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction Phosphorylated tau (p‐tau) in cerebrospinal fluid (CSF) is an established
Alzheimer's disease (AD) biomarker. Novel immunoassays targeting N‐terminal and mid …

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease

S Janelidze, D Bali, NJ Ashton, NR Barthélemy… - Brain, 2023 - academic.oup.com
Plasma phospho-tau (p-tau) species have emerged as the most promising blood-based
biomarkers of Alzheimer's disease. Here, we performed a head-to-head comparison of p …

Plasma and CSF biomarkers in a memory clinic: head‐to‐head comparison of phosphorylated tau immunoassays

NJ Ashton, A Puig‐Pijoan, M Milà‐Alomà… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Direct comparisons of the main blood phosphorylated tau immunoassays in
memory clinic populations are needed to understand possible differences. Methods In the …

Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort

AJ Mendes, F Ribaldi, A Lathuiliere, NJ Ashton… - Journal of …, 2024 - Springer
Background and objective Phosphorylated tau (p-tau) 217 has recently received attention
because it seems more reliable than other p-tau variants for identifying Alzheimer's disease …

The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease

J Simrén, A Leuzy, TK Karikari, A Hye… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction This study investigated the diagnostic and disease‐monitoring potential of
plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) …

Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease

J Spiegel, E Pirraglia, RS Osorio… - Journal of …, 2015 - journals.sagepub.com
Cerebrospinal fluid (CSF) measures of phosphorylated-tau (P-tau) 231 and P-tau181 are
two biomarkers for the identification of tau pathology as related to Alzheimer's disease (AD) …