Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …

Nitrogen-containing compounds are the most common structural architectures in drug
candidates, natural and biological products, and small-molecule therapeutics. Within the …

Conspectus α-Amino acids (αAA) are one of the most useful chiral building blocks for
synthesis. There are numerous general strategies that have commonly been used for αAA …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

Conspectus In recent years, carbon–hydrogen bond functionalization has evolved from an
organometallic curiosity to a tool used in mainstream applications in the synthesis of …

A highly efficient and generally applicable method has been developed to functionalize the
ortho-C (sp2)–H bonds of picolinamide (PA)-protected benzylamine substrates with a broad …

Conspectus Aromatic structures are widespread motifs throughout organic chemistry, and C–
H activation has been recognized as a major tool for enabling their sustainable and efficient …

Pd-catalyzed C–H functionalizations promoted by transient directing groups remain largely
limited to C–H arylation only. Herein, we report a diverse set of ortho-C (sp2)–H …

The metal-catalyzed “cascade C–H activation/annulation” is a highly promising approach to
the construction of aromatic and heteroaromatic compounds. In this context, Pd-complexes …

The development of methods for the direct conversion of carbonshydrogen bonds into
carbon-oxygen, carbon-halogen, carbon-nitrogen, carbon-sulfur, and carbon-carbon bonds …