The gut microbiome modulates colon tumorigenesis

JP Zackular, NT Baxter, KD Iverson, WD Sadler… - MBio, 2013 - Am Soc Microbiol
Recent studies have shown that individuals with colorectal cancer have an altered gut
microbiome compared to healthy controls. It remains unclear whether these differences are …

Manipulation of the gut microbiota reveals role in colon tumorigenesis

JP Zackular, NT Baxter, GY Chen, PD Schloss - MSphere, 2016 - Am Soc Microbiol
There is growing evidence that individuals with colonic adenomas and carcinomas harbor a
distinct microbiota. Alterations to the gut microbiota may allow the outgrowth of bacterial …

[HTML][HTML] Structure of the gut microbiome following colonization with human feces determines colonic tumor burden

NT Baxter, JP Zackular, GY Chen, PD Schloss - Microbiome, 2014 - Springer
Background A growing body of evidence indicates that the gut microbiome plays a role in
the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that …

[HTML][HTML] Microbiome in colorectal cancer: how to get from meta-omics to mechanism?

D Ternes, J Karta, M Tsenkova, P Wilmes, S Haan… - Trends in …, 2020 - cell.com
Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

[HTML][HTML] Analysis of the intestinal lumen microbiota in an animal model of colorectal cancer

Q Zhu, Z Jin, W Wu, R Gao, B Guo, Z Gao, Y Yang… - PloS one, 2014 - journals.plos.org
Recent reports have suggested that multiple factors such as host genetics, environment and
diet can promote the progression of healthy mucosa towards sporadic colorectal carcinoma …

[HTML][HTML] The intestinal microbiota in colorectal cancer

H Tilg, TE Adolph, RR Gerner, AR Moschen - Cancer cell, 2018 - cell.com
Experimental evidence from the past years highlights a key role for the intestinal microbiota
in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on …

[HTML][HTML] Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

E Saus, S Iraola-Guzmán, JR Willis… - Molecular aspects of …, 2019 - Elsevier
The gastrointestinal tract harbors most of the microbiota associated with humans. In recent
years, there has been a surge of interest in assessing the relationships between the gut …

[HTML][HTML] Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer

X Liang, H Li, G Tian, S Li - Scientific reports, 2014 - nature.com
Bacterial colonisation of the gut is involved in the development of colitis-associated
colorectal cancer. However, it remains unclear how the gut microbiota dynamically shifts …

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

W Zhu, N Miyata, MG Winter, A Arenales… - Journal of experimental …, 2019 - rupress.org
Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-
producing E. coli strains, are risk factors for the development of colorectal cancer. Here, we …

[HTML][HTML] Gut microbiota modulate CD8 T cell responses to influence colitis-associated tumorigenesis

IY Amy, L Zhao, KA Eaton, S Ho, J Chen, S Poe… - Cell reports, 2020 - cell.com
There is increasing evidence that gut microbiome perturbations, also known as dysbiosis,
can influence colorectal cancer development. To understand the mechanisms by which the …