We have demonstrated that phenylacetate (PA)-induced cell cycle arrest in human prostate
cancer is mediated by increase of p27. In this study, we further investigated the mechanism …

The F-box protein Skp2 (Fbl1) is a positive regulator of G1-S transition and promotes
ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its …

Treatment with millimolar concentrations of phenylacetate (PA), results in cytostasis, growth
inhibition and differentiation in several human cancer cell lines, including prostate cancer …

Prostate cancer is the most commonly diagnosed tumor in men in the United States. Patients
with hormone-refractory prostate cancer are often treated with paclitaxel, but most of them …

Purpose: The purpose is to investigate the clinical relevance of altered patterns of p27 and
Skp2 expression in African-American patients with localized prostate cancer. The …

Background The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is
downregulated in the majority of human prostate cancers. The mechanism of p27 down …

BACKGROUND: In several human cancers, overexpression of Skp2 (S-phase kinase
associated protein 2), which targets p27 for degradation, portends a poorer prognosis. We …

Purpose: Prostate carcinomas show a low level of the cell cycle inhibitor p27, which
correlates with tumor aggressiveness. In tumors p27 is of the WT species and its …

OBJECTIVES: To analyze p27 and S-phase kinase-associated protein 2 (Skp2) expression
in upper urinary tract transitional cell carcinoma (TCC) with respect to biologic significance …

Overexpression of Skp2, the ubiquitin ligase subunit that targets p27 for degradation, is often
observed in cancers, and is associated with aggressive tumor proliferation and poor …