Vascular remodeling in host tissues surrounding growing tumors is implicated in the
successful development of tumor neovasculature. Cooperation between vascular …

Objective. Angiopoietin/Tie2 system with vascular endothelial growth factor (VEFG) is known
to be important for the initiation of angiogenesis in tumors. The aim was to evaluate whether …

Abstract Angiopoietin-2 (Ang-2) is a conditional antagonist and agonist for the endothelium-
specific Tie-2 receptor. Although endogenous Ang-2 cooperates with vascular endothelial …

Our analyses in several different tumor settings challenge the prevailing view that
malignancies and metastases generally initiate as avascular masses that only belatedly …

Angiopoietins have been increasingly implicated to play important roles in blood vessel
formation, remodeling, maturation, and maintenance. However, their roles in tumor …

Objective: The recent discovery of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) has
provided novel and important insights into the molecular mechanisms of blood vessel …

Abstracts The Angiopoietin/Tie system acts as a vascular specific ligand/receptor system to
control endothelial cell survival and vascular maturation. The Angiopoietin family includes …

Angiopoietin/tyrosine protein kinase receptor Tie-2 signaling in endothelial cells plays an
essential role in angiogenesis and wound healing. Angiopoietin-1 (Ang-1) is crucial for …

Glioblastomas are highly vascular tumors which overexpress the angiogenesis factor
vascular endothelial growth factor (VEGF). VEGF and its receptors, VEGF-R1 and VEGF-R2 …

Members of the Angiopoietin family regulate various aspects of physiologic and pathologic
angiogenesis. Although Angiopoietin-1 (Ang-1) decreases endothelial cell permeability and …