[HTML][HTML] The role of interleukin-10 in the pathogenesis of bacterial infection

T Van Der Poll, A Marchant… - Clinical Microbiology and …, 1997 - Elsevier
Infection is associated with enhanced production of cytokines, low-molecular-weight
proteins important for the orchestration of inflammatory processes. Research on the role of …

Recent insights into microbial triggers of interleukin-10 production in the host and the impact on infectious disease pathogenesis

BL Duell, CK Tan, AJ Carey, F Wu… - FEMS Immunology & …, 2012 - academic.oup.com
Since its initial description as a Th2-cytokine antagonistic to interferon-alpha and
granulocyte-macrophage colony-stimulating factor, many studies have shown various anti …

The role of interleukin-10 in critical illness

SM Opal, CE Huber - Current Opinion in Infectious Diseases, 2000 - journals.lww.com
Interleukin-10 is the most potent anti-inflammatory cytokine yet identified. It has multiple
actions affecting the innate immune system as well as humoral and cellular immune …

Opposing roles of IL-10 in acute bacterial infection

HF Peñaloza, BM Schultz, PA Nieto, GA Salazar… - Cytokine & growth factor …, 2016 - Elsevier
Abstract Interleukin-10 (IL-10) is recognized as an anti-inflammatory cytokine that
downmodulates inflammatory immune responses at multiple levels. In innate cells …

Expanding the current knowledge about the role of interleukin-10 to major concerning bacteria

HF Peñaloza, LP Noguera, CA Riedel… - Frontiers in …, 2018 - frontiersin.org
Interleukin-10 (IL-10) is one of the most important anti-inflammatory cytokine produced
during bacterial infection. Two related phenomena explain the importance of IL-10 …

IL-10: the master regulator of immunity to infection

KN Couper, DG Blount, EM Riley - The Journal of Immunology, 2008 - journals.aai.org
IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK
cells, and macrophages, all of which are required for optimal pathogen clearance but also …

Interleukin-10: cytokines in anti-inflammation and tolerance

A Howes, P Stimpson, P Redford, L Gabrysova… - … Frontiers: Regulation of …, 2014 - Springer
Abstract Interleukin (IL)-10 is an immunosuppressive cytokine produced by many cells of the
innate and adaptive immune response, including macrophages, dendritic cells, B cells, and …

Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens

JC Cyktor, J Turner - Infection and immunity, 2011 - Am Soc Microbiol
The generation of an effective immune response against an infection while also limiting
tissue damage requires a delicate balance between pro-and anti-inflammatory responses …

Interleukin-10: potential benefits and possible risks in clinical infectious diseases

SM Opal, JC Wherry, P Grint - Clinical infectious diseases, 1998 - academic.oup.com
Abstract Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the
synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2 …

Interleukin-12 in infectious diseases

L Romani, P Puccetti, F Bistoni - Clinical microbiology reviews, 1997 - Am Soc Microbiol
Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …