Tumorigenesis requires the concerted action of multiple pathways, including pathways that
stimulate proliferation and increase metabolism. Progesterone receptor membrane …

Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …

Cancer is one of the leading causes of death in America, and there is an urgent need for
new therapeutic approaches. The progesterone receptor membrane component 1 …

Progesterone receptor membrane component (PGRMC) proteins play important roles in
tumor growth, progression, and chemoresistance, of which PGRMC1 is the best …

Background PGRMC1 (progesterone receptor membrane component 1) is a highly
conserved heme binding protein, which is overexpressed especially in hormone receptor …

Hormone signaling is important in a number of disease states, and hormone receptors are
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …

Tumorigenesis requires the concerted action of multiple pathways, including pathways that
stimulate proliferation and metabolism. Epidermal growth factor receptor (EGFR) is a …

PGRMC2 (progesterone receptor membrane component 2) is highly homologous if
compared with PGRMC1, a cytochrome-related protein, which is induced in several cancers …

Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …

Triple negative breast cancers (TNBCs) are highly aggressive and grow in response to sex
steroid hormones despite lacking expression of the classical estrogen (E2) and …