Epigenetic alterations are considered to be very influential in both the normal and disease
states of an organism. These alterations include methylation, acetylation, phosphorylation …

Epigenetics is a molecular phenomenon that pertains to heritable changes in gene
expression that do not involve changes in the DNA sequence. Epigenetic modifications in a …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Cancer development is driven by the accumulation of alterations affecting the structure and
function of the genome. Whereas genetic changes disrupt the DNA sequence, epigenetic …

Personalized medicine is defined by therapy decisions tailored to individual patients, aiming
to improve therapeutic efficiencies and to minimize side effects. The current clinical practice …

Introduction: Epigenetics is the study of reversible modifications to chromatin and their
extensive and profound effects on gene regulation. To date, the role of epigenetics in …

Alterations in the genome and the epigenome are common in most cancers. Changes in
epigenetic signatures, including aberrant DNA methylation and histone deacetylation, are …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Deregulation of the epigenome is now recognized as a major mechanism involved in the
development and progression of human diseases such as cancer. As opposed to the …