The IRX1 tumor suppressor gene is located on 5p15. 33, a cancer susceptibility locus. Loss
of heterozygosity of 5p15. 33 in gastric cancer was identified in our previous work. In this …

Simple Summary Lung cancer is one of the most commonly diagnosed cancers worldwide
and the most common cause of cancer-related deaths. During lung carcinogenesis …

IRX1 is originally characterized as a tumor suppressor gene of gastric cancer (GC) by our
group based on serially original studies. However, the molecular regulatory mechanisms of …

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the
lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma …

The overexpression of IRX1 gene correlates with the growth arrest in gastric cancer.
Furthermore, overexpression of IRX1 gene suppresses peritoneal spreading and long …

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. As tumor
metastasis is the leading cause of death in patients with CRC, it is important to elucidate the …

Interferon regulatory factor 6 (IRF6) acts as a tumor suppressor and controls cell
differentiation in ectodermal and craniofacial tissues by regulating expression of target …

Copy number alterations are frequently found in colorectal cancer (CRC), and recurrent
gains or losses are likely to correspond to regions harbouring genes that promote or impede …

Osteosarcoma is the most common type of human primary malignant bone tumor with a
potential propensity for local invasion and distant metastasis. Thus, this study focused on the …

Promoter hypermethylation has become apparent as a common mechanism of gene
silencing in cancer. Based on our published microarray expression data, we noticed a …