Serotonin enhances β-endorphin secretion to lower plasma glucose in streptozotocin-induced diabetic rats

TC Chi, YJ Ho, WP Chen, TL Chi, SS Lee, JT Cheng… - Life sciences, 2007 - Elsevier
Although serotonin, serotonin uptake inhibitors and serotonin precursors (including
tryptophan or 5-hydroxytryptophan) are known to have hypoglycemic action in rodents or …

Brain serotonin depletion attenuates diabetogenic effects of streptozotocin

YF Yang, MT Lin - American Journal of Physiology …, 1995 - journals.physiology.org
The diabetogenic effects of streptozotocin (STZ) were studied on blood glucose, plasma
insulin, feeding and drinking, body weight, islet morphology, and hypothalamic serotonin (5 …

Serotonergic receptor upregulation in cerebral cortex and down regulation in brainstem of streptozotocin induced diabetic rats: Antagonism by pyridoxine and insulin

PM Abraham, TR Anju, S Jayanarayanan… - Neuroscience …, 2010 - Elsevier
Insulin secretion and glucose homeostasis is implicated through serotonergic function.
Pyridoxine is involved in decarboxylation step in synthesis of serotonin. The present study …

Mediation of Endogenous β‐Endorphin by Tetrandrine to Lower Plasma Glucose in Streptozotocin‐Induced Diabetic Rats

JH Hsu, YC Wu, SS Liou, IM Liu… - Evidence‐Based …, 2004 - Wiley Online Library
The role of β‐endorphin in the plasma glucose‐lowering action of tetrandrine in
streptozotocin‐induced diabetic rats (STZ‐diabetic rats) was investigated. The plasma …

Plasma glucose-lowering effect of β-endorphin in streptozotocin-induced diabetic rats

JT Cheng, IM Liu, TF Tzeng, CC Tsai… - … and metabolic research, 2002 - thieme-connect.com
The effect of β-endorphin on plasma glucose levels was investigated in streptozotocin-
induced diabetic rats (STZ-diabetic rats). A dose-dependent lowering of plasma glucose was …

Effect of streptozotocin-induced diabetes mellitus on serotonin measures of peripheral tissues in rats

FJ Marti, JM Mi, M Aldegunde, G Atienza - Life sciences, 1994 - Elsevier
The present study was conducted to examine whether experimental diabetes (streptozotocin-
induced) promotes changes in serotonin (5HT) measures of peripheral tissue. Platelet-free …

Mediation of β-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats

IM Liu, WC Chen, JT Cheng - Journal of Pharmacology and Experimental …, 2003 - ASPET
We investigated the mechanism (s) by which isoferulic acid lowers plasma glucose levels in
streptozotocin-induced diabetic rats (STZ-diabetic rats). In STZ-diabetic rats, isoferulic acid …

Effects of serotonin on blood glucose and insulin levels of glucose and streptozotocin-treated mice

Y Sugimoto, I Kimura, J Yamada… - The Japanese Journal …, 1990 - jstage.jst.go.jp
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice.
In normal mice, 5-HT induced a dose-dependent hypo glycemia and an increase in serum …

Mechanism for blockade of angiotensin subtype 1 receptors to lower plasma glucose in streptozotocin‐induced diabetic rats

P Chan, IM Liu, TF Tzeng, TL Yang… - Diabetes, Obesity and …, 2007 - Wiley Online Library
Aims: We investigated the mechanism (s) by which valsartan, a selective antagonist of
angiotensin subtype 1 (AT1) receptor, decreased plasma glucose in streptozotocin (STZ) …

β-Endorphin–Induced Inhibition and Stimulation of Insulin Secretion in Normal Humans Is Glucose Dependent

D Giugliano, D Cozzolino, T Salvatore, R Torella… - Diabetes, 1988 - Am Diabetes Assoc
This study evaluated the effect of human β-endorphin on pancreatic hormone levels and
their responses to nutrient challenges in normal subjects. Infusion of 0.5 mg/h β-endorphin …