Central to understanding how nanoscale objects interact with living matter is the need for
reproducible and verifiable data that can be interpreted with confidence. Likely this will be …

Nanoparticles have opened new exciting avenues for both diagnostic and therapeutic
applications in human disease, and targeted nanoparticles are increasingly used as specific …

Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

Live cell imaging is a powerful tool to understand how nano-sized objects, such as the drug
carriers used for nanomedicine applications, are taken up and trafficked by cells. Here we …

Many applications of nanomedicines depend on the therapeutic gaining access to the
interior of cells. As most proteins and nanoparticles are taken up by endocytosis …

How small should nanoparticles be in order to travel freely through the cytosol similar to
proteins? Answering this question remains a challenge, because the majority of …

Understanding nanoparticle uptake by biological cells is fundamentally important to wide-
ranging fields from nanotoxicology to drug delivery. It is now accepted that the arrival of …

The use of nanoparticles (NPs) for enhanced drug delivery has been heavily explored
during the last decade. Within the field, it is has become increasingly apparent that the …

The diffusivity of macromolecules in the cytoplasm of eukaryotic cells varies over orders of
magnitude and dictates the kinetics of cellular processes. However, a general description …

Nanoparticles are promising vehicles for the precise delivery of molecular therapies to
diseased sites. Nanoparticles interact with a series of tissues and cells before they reach …