Biophysical properties of acid-sensing ion channels (ASICs)
S Gründer, M Pusch - Neuropharmacology, 2015 - Elsevier
Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely
sensitive to extracellular protons and can sense transient as well as sustained acidification …
sensitive to extracellular protons and can sense transient as well as sustained acidification …
Coupling structure with function in acid‐sensing ion channels: challenges in pursuit of proton sensors
ML Rook, M Musgaard… - The Journal of physiology, 2021 - Wiley Online Library
Acid‐sensing ion channels (ASICs) are a class of trimeric cation‐selective ion channels
activated by changes in pH within the physiological range. They are widely expressed in the …
activated by changes in pH within the physiological range. They are widely expressed in the …
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gating
S Vullo, G Bonifacio, S Roy, N Johner… - Proceedings of the …, 2017 - National Acad Sciences
Acid-sensing ion channels (ASICs) are proton-activated Na+ channels expressed in the
nervous system, where they are involved in learning, fear behaviors, neurodegeneration …
nervous system, where they are involved in learning, fear behaviors, neurodegeneration …
Proton-gated channels in PC12 cells
XP Chu, J Miesch, M Johnson, L Root… - Journal of …, 2002 - journals.physiology.org
Acid-sensing ion channels (ASICs) are expressed in various sensory and central neurons.
The functional role of these channels remains elusive. Complex subunit combinations and …
The functional role of these channels remains elusive. Complex subunit combinations and …
Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b
EL Bässler, TJ Ngo-Anh, HS Geisler… - Journal of Biological …, 2001 - ASBMB
Acid-sensing ion channels (ASICs) are activated by extracellular protons and are involved in
neurotransmission in the central nervous system, in pain perception, as well as in …
neurotransmission in the central nervous system, in pain perception, as well as in …
A nonproton ligand sensor in the acid-sensing ion channel
Y Yu, Z Chen, WG Li, H Cao, EG Feng, F Yu, H Liu… - Neuron, 2010 - cell.com
Acid-sensing ion channels (ASICs) have long been considered as extracellular proton (H+)-
gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic …
gated cation channels, and peripheral ASIC3 channels seem to be a natural sensor of acidic …
A molecular view of the function and pharmacology of acid-sensing ion channels
S Vullo, S Kellenberger - Pharmacological research, 2020 - Elsevier
The pH in the different tissues and organs of our body is kept within tight limits. Local pH
changes occur, however, temporarily under physiological conditions, as for example in …
changes occur, however, temporarily under physiological conditions, as for example in …
Acid sensing ion channels and acid nociception
GR Dube, A Elagoz, H Mangat - Current pharmaceutical design, 2009 - ingentaconnect.com
Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in
neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their …
neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their …
[HTML][HTML] Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a
S Gründer, X Chen - International journal of physiology …, 2010 - ncbi.nlm.nih.gov
Acid-sensing ion channels (ASICs) are H+-gated Na+ channels, which are present in most, if
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …
not all, neurons. The typical ASIC current is transient and is elicited by a rapid drop in the …
[HTML][HTML] Acid-sensing ion channels: focus on physiological and some pathological roles in the brain
Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …