The activation of poly (ADP-ribose) polymerase (PARP) in the reperfused brain after
ischemia has been assumed but never has been directly presented. Our studies indicate a …

We have investigated the role of poly (ADP‐ribose) polymerase (PARP) activation in rat
brain in a model of sublethal transient global ischemia. Adult male rats were subjected to 15 …

The brain inflammatory response induced by stroke contributes to cell death and impairs
neurogenesis. Poly (ADP-ribose) polymerase-1 (PARP-1) is a coactivator of the transcription …

Abstract Poly (ADP-ribose) polymerase 1 (PARP-1 EC 2.4. 2.30) is a nuclear enzyme that
plays an important role in cell survival and death. PARP is involved in DNA repair …

Poly (ADP-ribose) polymerase (PARP) is thought to play a physiological role in maintaining
genomic integrity and in the repair of DNA strand breaks. However, the activation of PARP …

THE activation of poly (ADP-ribose) polymerase (PARP) by free radical-damaged DNA plays
a pivotal role in mediating ischemia-reperfusion injury. The purpose of the present study was …

The nuclear enzyme poly (ADP-ribose) polymerase (PARP) is activated by oxidative stress
and plays a significant role in postischemic brain injury. We assessed the contribution of …

In the present study, the effect of poly (ADP-ribose) polymerase (PARP) inhibition on rat
cortical energy state was investigated at 24 h after global cerebral ischemia induced by …

Excessive activation of poly (ADP‐ribose) polymerase‐1 (PARP‐1) is known to develop
neuronal apoptosis, necrosis and inflammation after ischaemic brain injury. Therefore …

Cerebral ischemia induces excessive activation of poly (ADP-ribose) polymerase-1 (PARP-
1), leading to neuronal cell death and the development of post-ischemic dysfunction …