Chitosan (CS), a biocompatible and biodegradable material, can act as a non-viral delivery
vehicle with low toxicity. In this study, plasmid DNA (pDNA) and siRNA were encapsulated in …

Silica nanoparticle supported cationic lipids can effectively bind plasmidDNAs and transfect
mammalian cells with an efficiency that depends on both the particle size and lipid …

Functionalized calcium phosphate (hydroxyapatite) nanorods were freeze-dried in the
presence of the cryoprotectant trehalose, giving a storable and easily redispersible system …

Cancer remains a major global health challenge. Traditional chemotherapy often results in
side effects and drug resistance, necessitating the development of alternative treatment …

Various strategies for combination therapy to overcome current limitations in cancer therapy
have been actively investigated. Among them, simultaneous delivery of multiple drugs is a …

Effective gene delivery system plays an importmant role in the gene therapy. Mesoporous
silica nanoparticle (MSN) has become one potential gene delivery vector because of its high …

Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane
(MSN-NH 2) then l-histidine (MSN-His) for pDNA delivery in cells and in vivo. The …

Mesoporous silica nanoparticles have attracted much attention in recent years as drug and
gene delivery systems for biomedical applications. Among their most beneficial features for …

In somatic gene therapy, new concepts for the transfer of DNA into specific cell nuclei are of
interest. Inorganic nanoparticles have an interesting potential as DNA carrier system due to …

Conspectus Silica-based nanoparticles (SNPs) are a classic type of material employed in
biomedical applications because of their excellent biocompatibility and tailorable …