Distribution, interacting partners, and function of polysialic acid in the brainstem and spinal cord of adult rodents

S Shahbazian - 2022 - figshare.mq.edu.au
Glycans, a major class of biomolecules, are expressed on every cells surface and play an
important role in maintaining health with their perturbation causing disease. Polysialic acid …

Polysialic acid in the rat brainstem and thoracolumbar spinal cord: Distribution, cellular location, and comparison with mouse

S Shahbazian, P Bokiniec, BA Berning… - Journal of …, 2021 - Wiley Online Library
Polysialic acid (polySia), a homopolymer of α2, 8‐linked glycans, is a posttranslational
modification on a few glycoproteins, most commonly in the brain, on the neural cell adhesion …

Polysialic acid regulates sympathetic outflow by facilitating information transfer within the nucleus of the solitary tract

P Bokiniec, S Shahbazian, SJ McDougall… - Journal of …, 2017 - Soc Neuroscience
Expression of the large extracellular glycan, polysialic acid (polySia), is restricted in the
adult, to brain regions exhibiting high levels of plasticity or remodeling, including the …

Divergent impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid expression in immature neurons and interneurons of the adult cerebral cortex

J Nacher, R Guirado, E Varea, G Alonso-Llosa… - Neuroscience, 2010 - Elsevier
Polysialic acid (PSA) is a negatively charged carbohydrate polymer, which confers
antiadhesive properties to the neural cell adhesion molecule NCAM and facilitates cellular …

Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs …

SN Fewou, I Röckle, H Hildebrandt, M Eckhardt - Glycobiology, 2019 - academic.oup.com
A large body of the literature has demonstrated that the polysialic acid (polySia) modification
of the neural cell adhesion molecule (NCAM) is a key regulator of cellular interactions during …

Level and localization of polysialic acid is critical for early peripheral nerve regeneration

J Jungnickel, C Brämer, P Bronzlik… - Molecular and Cellular …, 2009 - Elsevier
PolySia, the most striking post-translational modification of the neural cell adhesion
molecule, is down-regulated during postnatal development. After peripheral nerve lesion …

Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development

K Angata, V Huckaby, B Ranscht… - … and cellular biology, 2007 - Taylor & Francis
Polysialic acid, which is synthesized by two polysialyltransferases, ST8SiaII and ST8SiaIV,
plays an essential role in brain development by modifying the neural cell adhesion molecule …

Chemical and biological methods for probing the structure and functions of polysialic acids

S Goswami, S Parashar, V Dwivedi… - Emerging Topics in …, 2018 - portlandpress.com
Owing to its poly-anionic charge and large hydrodynamic volume, polysialic acid (polySia)
attached to neural cell adhesion molecule regulates axon–axon and axon–substratum …

[HTML][HTML] News and views on polysialic acid: From tumor progression and brain development to psychiatric disorders, neurodegeneration, myelin repair and …

H Thiesler, M Küçükerden, L Gretenkort… - Frontiers in Cell and …, 2022 - frontiersin.org
Polysialic acid (polySia) is a sugar homopolymer consisting of at least eight glycosidically
linked sialic acid units. It is a posttranslational modification of a limited number of proteins …

Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4

A Mori, M Hane, Y Niimi, K Kitajima, C Sato - Glycobiology, 2017 - academic.oup.com
Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule
(NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains …