BACKGROUND: P-selectin antagonism has been shown to decrease thrombogenesis and
inflammation in animal models of deep venous thrombosis (DVT). OBJECTIVE: To …

Inhibition of P-selectin by antibody or selectin antagonist decreases inflammation and
thrombosis. This study evaluates the dose-response relationship using a selectin receptor …

Purpose: The purpose of this study was to compare the efficacy of P-selectin inhibition with
standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein …

Objective—Aptamers are oligonucleotides targeting protein–protein interactions with
pharmacokinetic profiles and activity reversal options. Although P-selectin and von …

P-selectin inhibition has been shown to decrease thrombogenesis in multiple animal
species. In this study, we show that a novel oral small-molecule inhibitor of P-selectin, PSI …

Objective There is an inter-relationship between thrombosis and inflammation. Previously,
we have shown the importance of P-selectin in thrombogenesis and thrombus resolution in …

P-selectin antagonism decreases thrombosis and inflammation in animal models of venous
thrombosis (VT) prophylaxis. This study defines results using a P-selectin receptor …

P-selectin inhibition has been evaluated as a therapeutic for prevention and treatment of
venous thrombosis. In this study, a novel oral small-molecule inhibitor of P-selectin, PSI-421 …

BACKGROUND: Vein wall injury after thrombosis is multifactorial but seems dependent on
thrombus and local thrombotic and inflammatory mechanisms. We hypothesized that …

Background. Post-deep vein thrombosis (DVT) venous insufficiency is a vexing problem
despite effective anticoagulation, and is characterized by vein wall fibrosis. This study tested …