The complex polysaccharide, heparan sulfate (HS), regulates airway development by
controlling cell-cell and cell-matrix communication via interactions with a vast number of …

Background Heparan sulfate (HS) is present on the surface of virtually all mammalian cells
and is a major component of the extracellular matrix (ECM), where it plays a pivotal role in …

Heparan sulfate proteoglycans (HSPGs) are essential to respiratory morphogenesis in
species as diverse as Drosophila and mice; they play a role in the regulation of numerous …

Heparan sulfate (HS) is a structurally complex polysaccharide located on the cell surface
and in the extracellular matrix, where it participates in numerous biological processes …

10 here is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the
role it plays in development and disease. There is a rapid change from the classical view of …

Heparan sulfates (HS), a class of glycosaminoglycans, are long linear complex
polysaccharides covalently attached to a protein core. The HS molecules are made up of …

There is an emerging interest in the extracellular matrix (ECM) of the lung, especially in the
role it plays in development and disease. There is a rapid change from the classical view of …

Heparan sulphate (HS) binds and regulates the distribution and activity of a number of
growth factors and chemokines, including interleukin-8 (1L-8). IL-8 is a primary stimulus for …

Pulmonary hypoplasia (PH) is a leading contributor to the lethality of congenital
diaphragmatic hernia (CDH). Studies now suggest that PH arises prior to visceral herniation …

Signaling by fibroblast growth factor 10 (FGF10) through FGFR2b is essential for lung
development. Heparan sulfates (HS) are major modulators of growth factor binding and …