Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein

B Wolff, G Cohen, J Hauber, D Meshcheryakova… - Experimental cell …, 1995 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev, which is required
for the cytoplasmic expression of unspliced and incompletely spliced viral mRNAs, is located …

Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev

S Kubota, R Furuta, M Maki, M Hatanaka - Journal of virology, 1992 - Am Soc Microbiol
A nonfunctional mutant of human immunodeficiency virus type 1 Rev was created by
deleting seven amino acid residues within the nucleolar targeting signal. This mutant Rev …

Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention

DM D'AGOSTINO, V Ciminale… - AIDS research and …, 1995 - liebertpub.com
We have explored the mechanism directing the intracellular trafficking and nucleolar
accumulation of the human immunodeficiency virus type 1 (HIV-1) Rev protein. Treatment of …

Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein

S Kubota, L Duan, RA Furuta, M Hatanaka… - Journal of …, 1996 - Am Soc Microbiol
Rev, a major regulatory protein of human immunodeficiency virus type 1, has been
demonstrated to shuttle between the nucleus and cytoplasm of infected cells. The fate of the …

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

BK Felber, M Hadzopoulou-Cladaras… - Proceedings of the …, 1989 - National Acad Sciences
rev (trs/art) is an essential human immunodeficiency virus type 1 (HIV-1) regulatory protein.
rev increases the levels of the gag-and env-producing mRNAs via a cis-acting element in …

Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function

AW Cochrane, A Perkins, CA Rosen - Journal of virology, 1990 - Am Soc Microbiol
The human immunodeficiency virus rev gene product regulates the expression of viral
structural genes. It was recently shown that Rev regulates the export of viral structural …

In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function

SJ Arrigo, S Heaphy, JK Haines - Journal of virology, 1992 - Am Soc Microbiol
The Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1) is required
for protein expression from the HIV-1 RNAs which contain a binding site for the Rev protein …

Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA

S Iacampo, A Cochrane - Journal of virology, 1996 - Am Soc Microbiol
Synthesis of human immunodeficiency virus structural proteins is dependent on expression
of the virus-encoded Rev protein due to the constitutive nuclear sequestration of mRNAs …

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

MH Malim, DF McCARN, LS Tiley, BR Cullen - Journal of virology, 1991 - Am Soc Microbiol
Replication of human immunodeficiency virus type 1 requires the functional expression of
the virally encoded Rev protein. The binding of this nuclear trans activator to its viral target …

Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization

LK Venkatesh, S Mohammed, G Chinnadurai - Virology, 1990 - Elsevier
The rev gene of human immunodeficiency virus type 1 (HIV-1) encodes a 116 amino acid
nuclear regulatory protein (Rev) that increases the cytoplasmic expression of viral mRNAs …