Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis

B Zhang, X Liu, E Lambert, G Mas, S Hiller… - Nature structural & …, 2020 - nature.com
Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria,
including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell …

Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS

D Lu, ME Wörmann, X Zhang… - Proceedings of the …, 2009 - National Acad Sciences
Staphylococcus aureus synthesizes polyglycerol-phosphate lipoteichoic acid (LTA) from
phosphatidylglycerol. LtaS, a predicted membrane protein with 5 N-terminal transmembrane …

Proteolytic cleavage inactivates the Staphylococcus aureus lipoteichoic acid synthase

ME Wörmann, NT Reichmann, CL Malone… - Journal of …, 2011 - Am Soc Microbiol
Lipoteichoic acid (LTA) is a crucial cell envelope component in Gram-positive bacteria. In
Staphylococcus aureus, the polyglycerolphosphate LTA molecule is synthesized by LtaS, a …

Genes Required for Glycolipid Synthesis and Lipoteichoic Acid Anchoring in Staphylococcus aureus

A Gründling, O Schneewind - Journal of bacteriology, 2007 - Am Soc Microbiol
Staphylococcus aureus lipoteichoic acid (LTA) is composed of a linear 1, 3-linked
polyglycerolphosphate chain and is tethered to the bacterial membrane by a glycolipid …

Lipoteichoic acid biosynthesis: two steps forwards, one step sideways?

O Rahman, LG Dover, IC Sutcliffe - Trends in microbiology, 2009 - cell.com
Lipoteichoic acids (LTAs) are membrane-anchored molecules in the cell envelopes of Gram-
positive bacteria. Until recently, they were considered to be restricted to the Firmicutes …

Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus

A Gründling, O Schneewind - Proceedings of the National …, 2007 - National Acad Sciences
Lipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the
envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or …

Increased flexibility in the use of exogenous lipoic acid by Staphylococcus aureus

I Laczkovich, WP Teoh, S Flury… - Molecular …, 2018 - Wiley Online Library
Lipoic acid is a cofactor required for intermediary metabolism that is either synthesized de
novo or acquired from environmental sources. The bacterial pathogen Staphylococcus …

The cell wall polymer lipoteichoic acid becomes nonessential in Staphylococcus aureus cells lacking the ClpX chaperone

KT Bæk, L Bowman, C Millership, M Dupont Søgaard… - MBio, 2016 - Am Soc Microbiol
Lipoteichoic acid (LTA) is an important cell wall component of Gram-positive bacteria and a
promising target for the development of vaccines and antimicrobial compounds against …

The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity

AR Hesser, LM Matano, CR Vickery… - Journal of …, 2020 - Am Soc Microbiol
The opportunistic pathogen Staphylococcus aureus is protected by a cell envelope that is
crucial for viability. In addition to peptidoglycan, lipoteichoic acid (LTA) is an especially …

Mechanism of d-alanine transfer to teichoic acids shows how bacteria acylate cell envelope polymers

BJ Schultz, ED Snow, S Walker - Nature Microbiology, 2023 - nature.com
Bacterial cell envelope polymers are often modified with acyl esters that modulate
physiology, enhance pathogenesis and provide antibiotic resistance. Here, using the d …