Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway

H Wang, Q Xi, G Wu - Cancer medicine, 2016 - Wiley Online Library
Fatty acid synthase (Fasn) is the key metabolic enzyme that accounts for the terminal
catalytic step in fatty acid synthesis, which is hyperactivated in various tumors. In this study …

Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway

T Lu, L Sun, Z Wang, Y Zhang, Z He… - OncoTargets and …, 2019 - Taylor & Francis
Objective In the present study, we aimed to investigate the potential role of fatty acid
synthase (FASN) in the development and progression of colorectal cancer (CRC). Materials …

Fatty acid synthase is a prognostic marker and associated with immune infiltrating in gastric cancers precision medicine

Y Zhou, W Su, H Liu, T Chen, N Höti, H Pei… - Biomarkers in …, 2020 - Taylor & Francis
Aim: Fatty acid synthase (FASN), a key enzyme for de novo synthesis of fatty acids, has been
identified as an oncogene in some tumor types; however, the function of FASN in gastric …

[HTML][HTML] Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration

YY Zaytseva, JW Harris, MI Mitov, JT Kim… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Fatty acid synthase (FASN), a lipogenic enzyme, is upregulated in colorectal cancer (CRC).
Increased de novo lipid synthesis is thought to be a metabolic adaptation of cancer cells that …

Up-regulated FASN expression promotes transcoelomic metastasis of ovarian cancer cell through epithelial-mesenchymal transition

L Jiang, H Wang, J Li, X Fang, H Pan, X Yuan… - International journal of …, 2014 - mdpi.com
Fatty acid synthase (FASN), responsible for the de novo synthesis of fatty acids, has been
shown to act as an oncogene in various human cancers. However, the mechanisms by …

Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway

L Chang, P Wu, R Senthilkumar, X Tian, H Liu… - Journal of cancer …, 2016 - Springer
Purpose Altered cellular metabolism has received increased attention as an important
hallmark of cancer. Activation of FASN has been found to be involved in many human …

Tissue-specific downregulation of fatty acid synthase suppresses intestinal adenoma formation via coordinated reprograming of transcriptome and metabolism in the …

J Drury, LEA Young, TL Scott, CO Kelson, D He… - International Journal of …, 2022 - mdpi.com
Altered lipid metabolism is a potential target for therapeutic intervention in cancer.
Overexpression of Fatty Acid Synthase (FASN) correlates with poor prognosis in colorectal …

[HTML][HTML] Expression and roles of fatty acid synthase in hepatocellular carcinoma

Q Hao, T Li, X Zhang, P Gao, P Qiao… - Oncology …, 2014 - spandidos-publications.com
Cell metabolism abnormalities are closely related to tumor occurrence and development.
Fatty acid synthase (FASN) is the key molecule for catalyzing fatty acid synthesis. Increasing …

Fatty acid synthase contributes to epithelial‐mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β‐catenin pathway

W Zhang, S Wang, Y Jiang, Y Liu, X Yu… - Journal of Cellular …, 2020 - Wiley Online Library
Fatty acid synthase (FASN) has been shown to be selectively up‐regulated in cancer cells to
drive the development of cancer. However, the role and associated mechanism of FASN in …

Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer

YY Zaytseva, VA Elliott, P Rychahou… - …, 2014 - academic.oup.com
Upregulation of fatty acid synthase (FASN), a key enzyme of de novo lipogenesis, is
associated with metastasis in colorectal cancer (CRC). However, the mechanisms of …