How valid are animal models to evaluate treatments for pulmonary hypertension?
ME Campian, M Hardziyenka, MC Michel… - … archives of pharmacology, 2006 - Springer
Various animal models of pulmonary hypertension (PH) exist, among which injection of
monocrotaline (MCT) and exposure to hypoxia are used most frequently. These animal …
monocrotaline (MCT) and exposure to hypoxia are used most frequently. These animal …
Animal models of pulmonary arterial hypertension
R Naeije, L Dewachter - Revue des maladies respiratoires, 2007 - europepmc.org
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare syndrome of fatigue and
dyspnoea, caused by increased pulmonary vascular resistance and right heart failure …
dyspnoea, caused by increased pulmonary vascular resistance and right heart failure …
Pulmonary arterial hypertension in congenital heart disease: translational opportunities to study the reversibility of pulmonary vascular disease
Pulmonary arterial hypertension (PAH) is a progressive and lethal pulmonary vascular
disease (PVD). Although in recent years outcome has improved by new treatments that …
disease (PVD). Although in recent years outcome has improved by new treatments that …
The search for disease-modifying therapies in pulmonary hypertension
CSC Woodcock, SY Chan - Journal of cardiovascular …, 2019 - journals.sagepub.com
Pulmonary hypertension (PH) and its severe subtype pulmonary arterial hypertension (PAH)
encompass a set of multifactorial diseases defined by sustained elevation of pulmonary …
encompass a set of multifactorial diseases defined by sustained elevation of pulmonary …
The mouse through the looking glass: a new door into the pathophysiology of pulmonary hypertension
M Rabinovitch - Circulation research, 2004 - Am Heart Assoc
Idiopathic pulmonary artery hypertension (IPH) is a rare illness with a poor prognosis.
Whereas chronic intravenous prostacyclin relieves some of the symptoms of progressive …
Whereas chronic intravenous prostacyclin relieves some of the symptoms of progressive …
The metabolic theory of pulmonary arterial hypertension
R Paulin, ED Michelakis - Circulation research, 2014 - Am Heart Assoc
Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …
The evolving management and treatment options for patients with pulmonary hypertension: Current evidence and challenges
JW Swisher, E Weaver - Vascular Health and Risk Management, 2023 - Taylor & Francis
Pulmonary hypertension may develop as a disease process specific to pulmonary arteries
with no identifiable cause or may occur in relation to other cardiopulmonary and systemic …
with no identifiable cause or may occur in relation to other cardiopulmonary and systemic …
Emerging therapies and future directions in pulmonary arterial hypertension
V Gurtu, ED Michelakis - Canadian Journal of Cardiology, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is a complex obliterative vascular disease. It remains
deadly despite an explosion of basic research over the past 20 years that identified myriads …
deadly despite an explosion of basic research over the past 20 years that identified myriads …
[HTML][HTML] Pathological mechanisms and potential therapeutic targets of pulmonary arterial hypertension: a review
Y Xiao, PP Chen, RL Zhou, Y Zhang, Z Tian… - Aging and …, 2020 - ncbi.nlm.nih.gov
Pulmonary arterial hypertension (PAH) is a progressive cardiovascular disease
characterized by pulmonary vasculature reconstruction and right ventricular dysfunction. The …
characterized by pulmonary vasculature reconstruction and right ventricular dysfunction. The …
Promising therapeutic approaches in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a debilitating multifactorial disease characterized
by progressive pulmonary vascular remodeling, elevated pulmonary arterial pressure, and …
by progressive pulmonary vascular remodeling, elevated pulmonary arterial pressure, and …