Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting
primarily the population of motor neurons, even though a non-cell autonomous component …

The development of precise microdevices can be applied to the reconstruction of in vitro
human microenvironmental systems with biomimetic physiological conditions that have …

Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in
individual human genetic backgrounds and thus for developing precision medicine. Here …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

Amyotrophic Lateral Sclerosis (ALS) is a motor neurodegenerative disorder whose cellular
hallmarks are the progressive death of motor neurons (MNs) located in the anterior horn of …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex multifactorial disorder,
characterized by motor neuron loss with involvement of several other cell types, including …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Nowadays, the pathophysiology of several central nervous system (CNS) disorders is still
poorly understood, making difficult the identification of efficient treatments. CNS damages …

Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to
engineer cells into microscale tissues with native-like features and then extract …

Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …