Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is
fatal for most patients less than 3 years from when the first symptoms appear. The …

Movement of skeletal-muscle fibers is generated by the coordinated action of several cells
taking part within the locomotion circuit (motoneurons, sensory-neurons, Schwann cells …

Background: The most widely employed approach by cell biologists to performing in vitro
cell culture assays is the one using 2D plastic culture ware systems, which allows …

Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …

In this article, we review brain-on-a-chip models and associated underlying technologies.
Micro-nanofluidic systems of the brain can utilize the entire spectrum of organoid …

Amyotrophic lateral sclerosis (ALS) is one of the most complex motor neuron diseases. Even
though scientific discoveries are accelerating with an unprecedented pace, to date more …

Introduction: Amyotrophic lateral sclerosis (ALS) is a rapid adult-onset neurodegenerative
disorder characterised by the progressive loss of upper and lower motor neurons. Current …

The alteration in the neural circuits of both central and peripheral nervous systems is closely
related to the onset of neurodegenerative disorders (NDDs). Despite significant research …

Cell-to-cell communications are critical determinants of pathophysiological phenotypes, but
methodologies for their systematic elucidation are lacking. Herein, we propose an approach …

The nervous system plays an irreplaceable role in maintaining homeostasis and
coordinating with the external environment. However, the incidence of neurological …