Human pluripotent stem cell-derived astrocytes (hiPSC-A) and neurons (hiPSC-N) provide a
powerful tool for modeling Amyotrophic Lateral Sclerosis (ALS) pathophysiology in vitro …

Developing diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

ABSTRACT A wide range of genetic mouse models is available to help researchers dissect
human disease mechanisms. Each type of model has its own distinctive characteristics …

The human brain is a complex organ composed of many different types of cells
interconnected to create an organized system able to efficiently process information …

Amyotrophic lateral sclerosis (ALS) is a fatal condition characterized by the selective loss of
motor neurons in the motor cortex, brainstem, and spinal cord. Muscle involvement, muscle …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder resulting in
progressive degeneration of motoneurons. Peak of onset is around 60 years for the sporadic …

Recent findings suggest a pathologic role of skeletal muscle in amyotrophic lateral sclerosis
(ALS) onset and progression. However, the exact mechanism by which this occurs remains …

Organoids are becoming particularly popular in modeling diseases that are difficult to
reproduce in animals, due to anatomical differences in the structure of a given organ. Thus …

Abstract Development of “organ-on-a-chip” systems for neuroscience applications are
lagging due in part to the structural complexity of the nervous system and limited access of …

In this chapter, we present a new method, dynamic meta-analysis, which allows the
examination of the underlying system dynamics of ALS utilizing the wealth of existing …