Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled …

KT Shelton, J Qu, F Bilotta, EN Brown, G Cudemus… - BMJ open, 2018 - bmjopen.bmj.com
Introduction Delirium, which is prevalent in postcardiac surgical patients, is an acute brain
dysfunction characterised by disturbances in attention, awareness and cognition not …

Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm, randomised …

JZ Qu, A Mueller, TB McKay, MB Westover… - …, 2023 - thelancet.com
Background The delirium-sparing effect of nighttime dexmedetomidine has not been studied
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …

[HTML][HTML] Dexmedetomidine in prevention of postoperative delirium: a systematic review

J Fondeur, LE Mendez, M Srinivasan, RK Hamouda… - Cureus, 2022 - ncbi.nlm.nih.gov
Delirium is defined by the DSM-5 as a fluctuating course of disturbance in attention,
cognition, and awareness that develops over a short period without any pre-existing …

Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review

KJ Pavone, PZ Cacchione, RC Polomano, LA Winner… - Heart & Lung, 2018 - Elsevier
Delirium, an acute change in cognition and attention not secondary to a pre-existing
condition or dementia, affects nearly 40,000 hospitalized older adults in the United States …

[HTML][HTML] Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery

EA Karren, AB King, CG Hughes - Journal of Thoracic Disease, 2016 - ncbi.nlm.nih.gov
© Journal of Thoracic Disease. All rights reserved. J Thorac Dis 2016; 8 (12): E1759-E1762
jtd. amegroups. com those that are not intubated, reduces the risk of delirium in the …

Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial

X He, KM Cheng, YQ Duan, SS Xu, HR Gao, MY Miao… - BMC neurology, 2021 - Springer
Background Clinical trials have shown that dexmedetomidine might decrease the
occurrence of postoperative delirium after major surgery, but neurosurgical patients were …

Effect of low-dose dexmedetomidine on sleep quality in postoperative patients with mechanical ventilation in the intensive care unit: a pilot randomized trial

YM Sun, SN Zhu, C Zhang, SL Li, DX Wang - Frontiers in medicine, 2022 - frontiersin.org
Background Sleep disturbances are prevalent in patients requiring invasive mechanical
ventilation in the intensive care unit (ICU) and are associated with worse outcomes …

Effect of dexmedetomidine on postoperative delirium in patients undergoing brain tumour resections: study protocol of a randomised controlled trial

D Wang, R Li, S Li, J Wang, M Zeng, J Dong, X Liu… - BMJ open, 2021 - bmjopen.bmj.com
Introduction Postoperative delirium (POD) is a common complication. The incidence of POD
is about 25% in non-cardiac surgery and ranges from 10% to 30% in neurological …

[HTML][HTML] Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised …

X Duan, M Coburn, R Rossaint, RD Sanders… - British journal of …, 2018 - Elsevier
Background The influence of dexmedetomidine on postoperative delirium (POD) in adult
surgical patients remains controversial. We aimed to analyse whether dexmedetomidine use …

Strategies for prevention of postoperative delirium: a systematic review and meta-analysis of randomized trials

H Zhang, Y Lu, M Liu, Z Zou, L Wang, FY Xu, XY Shi - Critical Care, 2013 - Springer
Introduction The ideal measures to prevent postoperative delirium remain unestablished.
We conducted this systematic review and meta-analysis to clarify the significance of …