Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

D Sivadasan, K Venkatesan, JMM Mohamed… - 2024 - researchsquare.com
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low
oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors …

Application of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations

D Sivadasan, K Venkatesan, JMM Mohamed… - Scientific Reports, 2024 - nature.com
Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low
oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors …

[PDF][PDF] Lornoxicam-loaded nanosponges for controlled anti-inflammatory effect: in vitro/in vivo assessment

SM Shawky, MK Khalifa, HA Eassa - Int. J. Appl. Pharm, 2020 - academia.edu
Objective: To design a controlled topical delivery system of lornoxicam (LX) in order to
enhance skin permeation and treatment efficacy. Nanosponges were selected as a novel …

[PDF][PDF] LOXOPROFEN NANOSPONGES: FORMULATION, CHARACTERIZATION AND EX-VIVO STUDY

MY HAMZA, ZR ABD EL AZIZ, M Aly Kassem… - Int J App …, 2022 - academia.edu
Objective: The objective of this study is to optimize a nanosponge formulation for Loxoprofen
and then incorporating it into a gel formulation offering a controlled drug release, enhanced …

[PDF][PDF] Formulation of novel glycerin nanoparticles for enhancement the solubility of loratadine; application to transdermal hydrogel delivery system

HA Abou-Taleb, MA Hamd… - J Nanomed …, 2017 - researchgate.net
Owing to its slightly aqueous solubility, loratadine (LOR) is used in high doses in different
marketed formulations to achieve its desirable bioavailability. The aim of this work is to …

[PDF][PDF] Formulation and In Vitro Evaluation of Niosomal Gel of Loratadine: A Novel Topical Agent for Allergic Skin

S Bhattacharyya, U Mohan - Indian J Pharm Sci, 2023 - researchgate.net
Niosomes are non-ionic surfactant nanovesicles, used to entrap both hydrophilic and
hydrophobic drugs. Penetration of encapsulated drugs through niosomal vesicles can …

Design Development and Characterization of Clotrimazole Nano Sponge Gel

SRI CHARAN, K KISHORE, GV KUMAR - International Journal of Pharmacy …, 2023 - ijprt.org
Objectives: Nanosponge is a new concept for the drug delivery system. In the present
research work, an attempt was made to develop nanosponge based topical hydrogel …

Development and characterization of hydrogel system bearing minoxidil loaded β–cyclodextrin based nanosponges for topical delivery

R Ansari, R Maheshwari, SC Mahajan… - Drug Delivery …, 2014 - ingentaconnect.com
Minoxidil loaded nanosponges (NS) based hydrogel system was developed for topical
application on to the scalp in order to avoid the disadvantages associated with the Minoxidil …

Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: preparation, characterization, and in vivo evaluation

A Alshweiat, II Csóka, F Tömösi, T Janáky… - International journal of …, 2020 - Elsevier
The unique requirements of poorly water-soluble drug delivery have driven a great deal of
research into new formulations and routes of administration. This study investigates the use …

Formulation, development, and characterization of loratadine emulgel

CS Sharaff, P Renukuntla, H Peddapalli… - Journal of Applied …, 2024 - japtronline.com
Background: This study was to develop loratadine (LTD) emulgels to treat localized skin
allergy. Method: Initially oil-in-water emulsion was prepared by 3 different types of …