Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review
The metabolome is the set of small molecular mass organic compounds found in a given
biological media. It includes all organic substances naturally occurring from the metabolism …
biological media. It includes all organic substances naturally occurring from the metabolism …
NMR and MS Methods for Metabolomics
A Amberg, B Riefke, G Schlotterbeck, A Ross… - Drug safety evaluation …, 2017 - Springer
Metabolomics, also often referred as “metabolic profiling,” is the systematic profiling of
metabolites in biofluids or tissues of organisms and their temporal changes. In the last …
metabolites in biofluids or tissues of organisms and their temporal changes. In the last …
LC–MS-based metabolomics in the clinical laboratory
S Becker, L Kortz, C Helmschrodt, J Thiery… - … of Chromatography B, 2012 - Elsevier
The analysis of metabolites in human body fluids remains a challenge because of their
chemical diversity and dynamic concentration range. Liquid chromatography (LC) in …
chemical diversity and dynamic concentration range. Liquid chromatography (LC) in …
The role of metabolites and metabolomics in clinically applicable biomarkers of disease
Metabolomics allows the simultaneous and relative quantification of thousands of different
metabolites within a given sample using sensitive and specific methodologies such as gas …
metabolites within a given sample using sensitive and specific methodologies such as gas …
UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical research
Highlights•Metabolomics provides a very powerful tool in pharmaceutical and clinical
research.•Metabolomic biomarkers can improve personalized treatments.•Metabolomics can …
research.•Metabolomic biomarkers can improve personalized treatments.•Metabolomics can …
Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies
G Theodoridis, HG Gika… - Mass spectrometry reviews, 2011 - Wiley Online Library
Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …
biology. To perform metabolomics it is necessary to generate comprehensive “global” …
[HTML][HTML] Advances in high throughput LC/MS based metabolomics: A review
Properly implemented, metabolic and lipidomic profiling can provide a deeper
understanding of mammalian, plant and bacterial biology. These omics-tools have …
understanding of mammalian, plant and bacterial biology. These omics-tools have …
Metabolomics in toxicology: preclinical and clinical applications
DG Robertson, PB Watkins, MD Reily - Toxicological sciences, 2011 - academic.oup.com
Metabolomics first burst into the toxicology arena approximately 10–12 years ago,
experiencing rapid growth as a science in the intervening period (Fig. 1). Though …
experiencing rapid growth as a science in the intervening period (Fig. 1). Though …
NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review
Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …
assessed, identified and quantified in different biological samples. Metabolites are crucial …
Metabolomics technologies and metabolite identification
Metabolomics studies rely on the analysis of the multitude of small molecules (metabolites)
present in a biological system. Most commonly, metabolomics is heavily supported by mass …
present in a biological system. Most commonly, metabolomics is heavily supported by mass …