Applications of liquid chromatography coupled to mass spectrometry-based metabolomics in clinical chemistry and toxicology: A review

A Roux, D Lison, C Junot, JF Heilier - Clinical biochemistry, 2011 - Elsevier
The metabolome is the set of small molecular mass organic compounds found in a given
biological media. It includes all organic substances naturally occurring from the metabolism …

NMR and MS Methods for Metabolomics

A Amberg, B Riefke, G Schlotterbeck, A Ross… - Drug safety evaluation …, 2017 - Springer
Metabolomics, also often referred as “metabolic profiling,” is the systematic profiling of
metabolites in biofluids or tissues of organisms and their temporal changes. In the last …

LC–MS-based metabolomics in the clinical laboratory

S Becker, L Kortz, C Helmschrodt, J Thiery… - … of Chromatography B, 2012 - Elsevier
The analysis of metabolites in human body fluids remains a challenge because of their
chemical diversity and dynamic concentration range. Liquid chromatography (LC) in …

The role of metabolites and metabolomics in clinically applicable biomarkers of disease

M Mamas, WB Dunn, L Neyses, R Goodacre - Archives of toxicology, 2011 - Springer
Metabolomics allows the simultaneous and relative quantification of thousands of different
metabolites within a given sample using sensitive and specific methodologies such as gas …

UPLC–MS for metabolomics: a giant step forward in support of pharmaceutical research

AF Nassar, T Wu, SF Nassar, AV Wisnewski - Drug discovery today, 2017 - Elsevier
Highlights•Metabolomics provides a very powerful tool in pharmaceutical and clinical
research.•Metabolomic biomarkers can improve personalized treatments.•Metabolomics can …

Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies

G Theodoridis, HG Gika… - Mass spectrometry reviews, 2011 - Wiley Online Library
Metabonomics and metabolomics represent one of the three major platforms in systems
biology. To perform metabolomics it is necessary to generate comprehensive “global” …

[HTML][HTML] Advances in high throughput LC/MS based metabolomics: A review

RS Plumb, LA Gethings, PD Rainville, G Isaac… - TrAC Trends in …, 2023 - Elsevier
Properly implemented, metabolic and lipidomic profiling can provide a deeper
understanding of mammalian, plant and bacterial biology. These omics-tools have …

Metabolomics in toxicology: preclinical and clinical applications

DG Robertson, PB Watkins, MD Reily - Toxicological sciences, 2011 - academic.oup.com
Metabolomics first burst into the toxicology arena approximately 10–12 years ago,
experiencing rapid growth as a science in the intervening period (Fig. 1). Though …

NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review

A Smolinska, L Blanchet, LMC Buydens… - Analytica chimica …, 2012 - Elsevier
Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …

Metabolomics technologies and metabolite identification

S Moco, J Vervoort, RJ Bino, RCH De Vos… - TrAC Trends in Analytical …, 2007 - Elsevier
Metabolomics studies rely on the analysis of the multitude of small molecules (metabolites)
present in a biological system. Most commonly, metabolomics is heavily supported by mass …