Mechanisms determining the chronicity or the pattern of clinical course of hepatitis C virus
(HCV) infections have not been clarified. Recently, CD81 was reported to bind the E2 …

Several cell surface molecules have hepatitis C virus (HCV) binding properties and may
serve as receptors facilitating viral entry into cells. The large extracellular loop (LEL) of …

The hepatitis C virus (HCV) envelope (E) 2 protein interacts with the cellular receptor CD81
leading to modulation of B and T cell function. Recently, a higher binding affinity of subtype …

The expression of CD81, a cell receptor for hepatitis C virus, was examined on cancer cells
in hepatocellular carcinoma (HCC) C (n= 29) to clarify its clinical role. CD81 was expressed …

CD81 protein has been shown to bind hepatitis C virus (HCV) envelope 2 (E2) glycoprotein
in vitro and may act as a (co) receptor for HCV. Regulation of CD81 expression by interferon …

Aim: The aim of the present study is to study the mechanism of entry of hepatitis C virus
(HCV) into human cells. We examined the in vitro binding of HCV to various human cell lines …

The level of CD81 cell surface expression, a cellular co-receptor for hepatitis C virus (HCV),
is critical for productive HCV infection of host cells. In addition, the cross-linking of HCV-E2 …

All PCR products showed a single band at approximately 900 bp on ethidium bromide-
stained gels. Sequencing of PCR products showed a nucleotide substitution C596= T in one …

We previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …

Chronic hepatitis C virus (HCV) infection is frequently associated with type II mixed
cryoglobulinaemia (MC), a benign lymphoproliferative disease (LPD). More recently, HCV …