Cell cycle arrest and apoptosis-inducing ability of benzimidazole derivatives: design, synthesis, docking, and biological evaluation
S Nazreen, ASA Almalki, SEI Elbehairi, AA Shati… - Molecules, 2022 - mdpi.com
In the current study, new benzimidazole-based 1, 3, 4-oxadiazole derivatives have been
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
synthesized and characterized by NMR, IR, MS, and elemental analysis. The final …
Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies
BGM Youssif, MM Morcoss, S Bräse, M Abdel-Aziz… - Molecules, 2024 - mdpi.com
A new class of benzimidazole-based derivatives (4a–j, 5, and 6) with potential dual
inhibition of EGFR and BRAFV600E has been developed. The newly synthesized …
inhibition of EGFR and BRAFV600E has been developed. The newly synthesized …
Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies
Multi-target inhibitors represent useful anticancer agents with superior therapeutic attributes.
Here in, two novel series of benzimidazole-triazole hybrids were designed, synthesised as …
Here in, two novel series of benzimidazole-triazole hybrids were designed, synthesised as …
Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
Synthesis, biological evaluation, and molecular docking of new benzimidazole-1, 2, 3-triazole hybrids as antibacterial and antitumor agents
S Ahmed Saleh Alzahrani, S Nazreen… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A new series of benzimidazole-1, 2, 3-triazole hybrids have been successfully accomplished
by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The …
by the Click chemistry of different aromatic azides and propargylated benzimidazole (4). The …
Synthesis and anticancer activity of novel benzimidazole and benzothiazole derivatives against HepG2 liver cancer cells
Most of cancer chemotherapeutics and chemopreventives exert their effects by triggering
apoptotic cell death. In this study, novel benzimidazole and benzothiazole derivatives have …
apoptotic cell death. In this study, novel benzimidazole and benzothiazole derivatives have …
Benzoxazole-appended piperidine derivatives as novel anticancer candidates against breast cancer
Novel series of benzoxazole-appended piperidine derivatives were planned, synthesized
and screened against two breast cancer cell lines. Considerable antiproliferative activity was …
and screened against two breast cancer cell lines. Considerable antiproliferative activity was …
Synthesis of stable benzimidazole derivatives bearing pyrazole as anticancer and EGFR receptor inhibitors
A new series of benzimidazole linked pyrazole derivatives were synthesized by
cyclocondensation reaction through one-pot multicomponent reaction in absolute ethanol …
cyclocondensation reaction through one-pot multicomponent reaction in absolute ethanol …
Novel benzimidazole derivatives: Synthesis, in vitro cytotoxicity, apoptosis and cell cycle studies
The aim of the study was to synthesize a new series of benzimidazole derivatives and to
investigate the underlying molecular mechanisms of the potential cell cycle inhibition and …
investigate the underlying molecular mechanisms of the potential cell cycle inhibition and …
Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives
B Ren, RC Liu, K Ji, JJ Tang, JM Gao - Bioorganic & medicinal chemistry …, 2021 - Elsevier
A series of novel pyrazole-benzimidazole derivatives (6–42) have been designed,
synthesized and evaluated for their in vitro antiproliferative activity against the HCT116, MCF …
synthesized and evaluated for their in vitro antiproliferative activity against the HCT116, MCF …