The mesolimbic system is known to play a role in self-administration of opioids and
psychostimulants. Although morphine and cocaine act by separate cellular mechanisms …

Imaging studies have provided new insights on the role of dopamine (DA) in drug abuse and
addiction in the human brain. These studies have shown that the reinforcing effects of drugs …

Imaging studies have revealed neurochemical and functional changes in the brains of drug-
addicted subjects that provide new insights into the mechanisms underlying addiction …

The main characteristics of cocaine addiction are compulsive drug use despite adverse
consequences and high rates of relapse during periods of abstinence. A current popular …

The rewarding effects of drugs of abuse have been linked to increases in dopamine
transmission. However, changes in brain chemistry and morphology that are produced in …

The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of
self‐administered cocaine to produce addiction‐like behavior in rodents, and to change the …

A prominent aspect of drug addiction is the ability of drug-associated cues to elicit craving
and facilitate relapse. Understanding the factors that regulate cue reactivity will be vital for …

A hallmark of drug addiction is the uncontrollable desire to consume drugs at the expense of
severe negative consequences. Moreover, addicts that successfully refrain from drug use …

There is considerable evidence that chronic exposure to cocaine is associated with low
striatal dopamine D2 receptor availability. In the present study we wished to determine …

Methylphenidate (MPH) is a commonly abused psychostimulant prescribed for the treatment
of attention deficit hyperactivity disorder. MPH has a mechanism of action similar to cocaine …