Cancer patients may exhibit normal or altered circadian rhythms in tumor and healthy
tissues. Four rhythms known to reflect circadian clock function were studied in 18 patients …

Circadian rhythms can be altered in severe illness such as cancer; the rest-activity circadian
cycle has been used as a reference for the administration of chemotherapy at specific times …

The clinical relevance of circadian rhythm modifications in patients on chemotherapy is
unknown. Even so, circadian parameter I< O before chemotherapy independently predicted …

Activity circadian rhythms were measured non-invasively in 30 patients with metastatic
colorectal cancer by wrist actigraphy, and compared with control data. Patients and control …

Drug absorption, transport, metabolism and/or elimination usually show 24 h changes in
both laboratory rodents and human beings. These variations in target cell exposure to drugs …

The rest/activity circadian cycle has been used as a reference for chemotherapy
administration at specific times to improve tolerability and efficacy. Because cancer …

The rest-activity circadian rhythm (CircAct) reflects the function of the circadian timing
system. In a prior single-institution study, the extent of CircAct perturbation independently …

The disruption of the circadian timing system (CTS), which rhythmically controls cellular
metabolism and proliferation, accelerated experimental cancer progression. A measure of …

Murine and human data have indicated that tumors and tumor‐bearing hosts may exhibit
nearly normal or markedly altered circadian rhythms. Amplitude damping, phase shifts …

The aim of the present study was to evaluate the characteristics of the circadian rest‐activity
rhythm of cancer patients. Thirty‐one in‐patients, consisting of 19 males and 12 females …