Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to
stimulation by Mycobacterium tuberculosis antigens without evidence of a clinically …

Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination |
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Introduction An improved understanding of factors explaining tuberculosis (TB) treatment
response is urgently needed to help clinicians optimise and personalise treatment and …

Tuberculosis (TB) remains one of the leading causes of death. Delayed diagnosis and
treatment of TB as well as an emergence of drug-resistant TB are major problems in …

Introduction Xpert MTB/RIF assay is used extensively for the detection of rifampicin-resistant
TB (RR-TB). RR-TB treatment monitoring is culture-based, although, in resource-limited …

Background Studies that validate new antituberculous regimens take much more time to
complete as mycobacteria tend to be cleared slowly with absence of valid biomarkers to …

Tuberculosis (TB) is a global health emergency and the need to develop better tools for its
management have never been urgent. We report a performance evaluation of rapid …

METHODS: We obtained sputum samples from 115 adult patients at ten international sites
with smear-positive pulmonary tuberculosis enrolled in TB Trials Consortium 29X, a phase 2 …

Sputum culture plays an important role in monitoring treatment response in patients with
multidrug-resistant tuberculosis (MDR-TB), and sputum culture conversion is a clinical tool …

Background Various studies have reported culture conversion at two months as a predictor
of successful treatment outcome in multidrug-resistant tuberculosis (MDR-TB). Objectives …