Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling …

ES Park, S Kang, K Yoo, MY Lee, HS Yoo… - Experimental cell …, 2013 - Elsevier
The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial wall is a
major cause of vascular disorders such as atherosclerosis and restenosis after angioplasty …

Inhibitory effects of docetaxel on platelet-derived growth factor (PDGF)-BB–induced proliferation of vascular smooth muscle cells through blocking PDGF-receptor β …

ES Park, JM Yoo, Y Lim, M Tudev, HS Yoo… - Journal of …, 2011 - jstage.jst.go.jp
The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial wall is an
important pathogenic factor for vascular disorders such as atherosclerosis and restenosis …

Platelet-derived growth factor stimulated vascular smooth muscle cell proliferation and its molecular mechanism.

J Li, SL Huang, ZG Guo - Acta Pharmacologica Sinica, 2000 - europepmc.org
Aim To study the molecular mechanism of platelet-derived growth factor (PDGF)-BB-
stimulated vascular smooth muscle cell (VSMC) proliferation. Methods DNA synthesis was …

Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21

S Hayashi, R Morishita, H Matsushita, H Nakagami… - …, 2000 - Am Heart Assoc
Although cAMP is an important second messenger that plays a pivotal role in the regulation
of platelet aggregation and dilatation of blood vessels, little is known about the action of …

[HTML][HTML] Zedoarondiol inhibits platelet-derived growth factor-induced vascular smooth muscle cells proliferation via regulating AMP-activated protein kinase signaling …

H Mao, T Tao, D Song, M Liu, X Wang, X Liu… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Vascular smooth muscle cells (VSMCs) proliferation contributes
significantly to atherosclerosis and in-stent restenosis. Platelet-derived growth factor-BB …

Concerted effect of transforming growth factor-β, cyclin inhibitor p21, and c-myc on smooth muscle cell proliferation

A Khanna - American Journal of Physiology-Heart and …, 2004 - journals.physiology.org
Increased aortic smooth muscle cell (SMC) proliferation is a key event in the pathogenesis of
atherosclerosis. Transforming growth factor-β (TGF-β) is one of the potent inhibitors of SMC …

Camptothecin inhibits the progression of NPC by regulating TGF‑β‑induced activation of the PI3K/AKT signaling pathway

BS Li, JY Huang, J Guan, LH Chen - Oncology Letters, 2018 - spandidos-publications.com
Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased
invasiveness, metastatic potential and tumor recurrence. Camptothecin has been …

Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway

ES Park, Y Lim, JT Hong, HS Yoo, CK Lee, MY Pyo… - Vascular …, 2010 - Elsevier
Vascular smooth muscle cells (VSMCs) are the main cellular component in the arterial wall,
and abnormal proliferation of VSMCs plays a central role in the pathogenesis of …

Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression

M Igata, H Motoshima, K Tsuruzoe, K Kojima… - Circulation …, 2005 - Am Heart Assoc
Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and
progression of vascular diseases, including atherosclerosis. We investigated whether the …

Ligustrazine attenuates the platelet‑derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal …

L Yu, X Huang, K Huang, C Gui… - Molecular …, 2015 - spandidos-publications.com
The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) leads to
intimal thickening of the aorta and is, therefore, important in the development of …