The neuroinflammatory basis of depression encompasses the detrimental role of otherwise
supportive non-neuronal cells and neuroinflammation in hampering neuronal function …

Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Chronic stress is a major risk factor for various psychiatric diseases, including depression; it
triggers various cellular and structural changes, resulting in the alteration of neurocircuitry …

Although there are a number of clinically effective treatments for depression, many patients
exhibit treatment resistance. Recent clinical and preclinical studies reveal that peripheral …

Depression has been widely accepted as a major psychiatric disease affecting nearly 350
million people worldwide. Research focus is now shifting from studying the extrinsic and …

Mood disorders are associated with persistently high rates of morbidity and mortality, despite
the widespread availability of antidepressant treatments. One limitation to extant therapeutic …

In a subset of patients, chronic exposure to stress is an etiological risk factor for
neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with …

There are several hypotheses concerning the underlying pathophysiological mechanisms of
major depression, which centre largely around adaptive changes in neuronal transmission …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Major depressive disorder (MDD) is a mood disorder of multifactorial origin affecting millions
of people worldwide. The alarming estimated rates of prevalence and relapse make it a …