Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis

O Higuchi, J Hamuro, M Motomura… - Annals of …, 2011 - Wiley Online Library
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, where
acetylcholine receptor (AChR), muscle‐specific kinase (MuSK), and low‐density lipoprotein …

Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis

C Shen, Y Lu, B Zhang, D Figueiredo… - The Journal of …, 2013 - Am Soc Clin Investig
Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction
(NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) …

Anti-LRP4 autoantibodies in AChR-and MuSK-antibody-negative myasthenia gravis

A Pevzner, B Schoser, K Peters, NC Cosma… - Journal of …, 2012 - Springer
Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic
transmission at the neuromuscular junction causing fluctuating muscle weakness with a …

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis

P Zisimopoulou, P Evangelakou, J Tzartos… - Journal of …, 2014 - Elsevier
Double-seronegative myasthenia gravis (dSN-MG, without detectable AChR and MuSK
antibodies) presents a serious gap in MG diagnosis and understanding. Recently …

Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis

B Zhang, JS Tzartos, M Belimezi, S Ragheb… - Archives of …, 2012 - jamanetwork.com
Objectives To determine whether patients with myasthenia gravis (MG) have serum
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is …

Multiple antibody detection in 'seronegative'myasthenia gravis patients

Y Hong, P Zisimopoulou, N Trakas… - European journal of …, 2017 - Wiley Online Library
Background and purpose Myasthenia gravis (MG) is an autoimmune disease caused by
antibody mediated impairment in the neuromuscular junction. Seronegative MG (SNMG) …

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

MG Huijbers, W Zhang, R Klooster… - Proceedings of the …, 2013 - National Acad Sciences
Myasthenia gravis (MG) is a severely debilitating autoimmune disease that is due to a
decrease in the efficiency of synaptic transmission at neuromuscular synapses. MG is …

MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters

I Koneczny, J Cossins, P Waters, D Beeson, A Vincent - PloS one, 2013 - journals.plos.org
A variable proportion of patients with generalized myasthenia gravis (MG) have
autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin …

Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4

JJGM Verschuuren, MG Huijbers, JJ Plomp, EH Niks… - Autoimmunity …, 2013 - Elsevier
Myasthenia gravis is caused by antibodies to the acetylcholine receptor, muscle-specific
kinase, low-density lipoprotein receptor-related protein 4, or possibly yet unidentified …

[HTML][HTML] Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms

WD Phillips, A Vincent - F1000Research, 2016 - ncbi.nlm.nih.gov
Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused
by antibodies that attack components of the postsynaptic membrane, impair neuromuscular …