Repeated bouts of resistance exercise attenuate mitogen-activated protein-kinase signal responses in rat skeletal muscle

J Takegaki, K Sase, S Fujita - Biochemical and biophysical research …, 2019 - Elsevier
Resistance exercise training induces skeletal muscle hypertrophy, but repeated bouts
gradually attenuate this anabolic effect. Attenuation of mechanistic target of rapamycin …

Resistance exercise induced mTORC1 signaling is not impaired by subsequent endurance exercise in human skeletal muscle

W Apró, L Wang, M Pontén… - American Journal of …, 2013 - journals.physiology.org
The current dogma is that the muscle adaptation to resistance exercise is blunted when
combined with endurance exercise. The suggested mechanism (based on rodent …

Repeated bouts of resistance exercise with short recovery periods activates mTOR signaling, but not protein synthesis, in mouse skeletal muscle

J Takegaki, R Ogasawara, Y Tamura… - Physiological …, 2017 - Wiley Online Library
The recovery period between bouts of exercise is one of the major factors influencing the
effects of resistance exercise, in addition to exercise intensity and volume. However, the …

The effect of repeated bouts of electrical stimulation‐induced muscle contractions on proteolytic signaling in rat skeletal muscle

T Kotani, J Takegaki, Y Tamura, K Kouzaki… - Physiological …, 2021 - Wiley Online Library
Mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in muscle protein
synthesis and repeated bouts of resistance exercise (RE) blunt mTORC1 activation …

[HTML][HTML] Repeated and interrupted resistance exercise induces the desensitization and re-sensitization of mTOR-related signaling in human skeletal muscle fibers

D Jacko, K Schaaf, L Masur, H Windoffer… - International journal of …, 2022 - mdpi.com
The acute resistance exercise (RE)-induced phosphorylation of mTOR-related signaling
proteins in skeletal muscle can be blunted after repeated RE. The time frame in which the …

Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1

A Philp, DL Hamilton, K Baar - Journal of Applied …, 2011 - journals.physiology.org
For over 10 years, we have known that the activation of the mammalian target of rapamycin
complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength …

Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation

M Miyazaki, N Moriya, T Takemasa - Physiological Reports, 2020 - Wiley Online Library
The regulation of cellular protein synthesis is a critical determinant of skeletal muscle growth
and hypertrophy in response to an increased workload such as resistance exercise. The …

Contraction mode itself does not determine the level of mTORC1 activity in rat skeletal muscle

S Ato, Y Makanae, K Kido, S Fujita - Physiological reports, 2016 - Wiley Online Library
Resistance training with eccentric contraction has been shown to augment muscle
hypertrophy more than other contraction modes do (ie, concentric and isometric contraction) …

mTOR signaling response to resistance exercise is altered by chronic resistance training and detraining in skeletal muscle

R Ogasawara, K Kobayashi, A Tsutaki… - Journal of applied …, 2013 - journals.physiology.org
Resistance training-induced muscle anabolism and subsequent hypertrophy occur most
rapidly during the early phase of training and become progressively slower over time …

The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle

R Ogasawara, K Sato, K Matsutani… - American Journal …, 2014 - journals.physiology.org
Concurrent training, a combination of endurance (EE) and resistance exercise (RE)
performed in succession, may compromise the muscle hypertrophic adaptations induced by …