[HTML][HTML] Comparative study of subcutaneous and orthotopic mouse models of prostate cancer: vascular perfusion, vasculature density, hypoxic burden and BB2r …

W Zhang, W Fan, S Rachagani, Z Zhou, SM Lele… - Scientific reports, 2019 - nature.com
The gastrin-releasing peptide receptor (BB2r) is overexpressed in a variety of cancers
including prostate cancer. As a consequence, the development of BB2r-targeted …

[HTML][HTML] Gastrin-releasing peptide receptor-based targeting using bombesin analogues is superior to metabolism-based targeting using choline for in vivo imaging of …

RPJ Schroeder, WM Van Weerden… - European journal of …, 2011 - Springer
Purpose Prostate cancer (PC) is a major health problem. Overexpression of the gastrin-
releasing peptide receptor (GRPR) in PC, but not in the hyperplastic prostate, provides a …

Preclinical pharmacokinetic, biodistribution, imaging and therapeutic efficacy of 177Lu-Labeled glycated bombesin analogue for gastrin-releasing peptide receptor …

JC Lim, EH Cho, JJ Kim, SM Choi, SY Lee… - Nuclear Medicine and …, 2015 - Elsevier
The gastrin-releasing peptide receptor (GRPR) has been shown to be overexpressed in
many human tumors, including prostate, colon, gastric, breast, pancreatic, and small cell …

Evaluation of Combined 177Lu-DOTA-8-AOC-BBN (7-14)NH2 GRP Receptor-Targeted Radiotherapy and Chemotherapy in PC-3 Human Prostate Tumor Cell …

CV Johnson, T Shelton, CJ Smith, L Ma… - Cancer biotherapy & …, 2006 - liebertpub.com
The focus of this study was to evaluate the therapeutic benefit of combined gastrin-releasing
peptide (GRP) receptor-targeted radiotherapy (TRT) with chemotherapy, using the PC-3 …

A Radiotracer for molecular imaging and therapy of gastrin-releasing peptide receptor–positive prostate cancer

IJ Bratanovic, C Zhang, Z Zhang, HT Kuo… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The gastrin-releasing peptide receptor (GRPR) is overexpressed in many solid
malignancies, particularly in prostate and breast cancers, among others. We synthesized …

18F-labeled bombesin analog for specific and effective targeting of prostate tumors expressing gastrin-releasing peptide receptors

M Honer, L Mu, T Stellfeld, K Graham… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Bombesin is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor
(GRPr), which is highly overexpressed on prostate cancer cells. In the present study, we …

Near‐infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases

QY Cai, P Yu, C Besch‐Williford, CJ Smith… - The …, 2013 - Wiley Online Library
BACKGROUND Development of high affinity and specificity molecular imaging probes that
increase accuracy for early detection of lymph node (LN) metastases is important for …

18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer

X Zhang, W Cai, F Cao, E Schreibmann… - Journal of Nuclear …, 2006 - Soc Nuclear Med
The gastrin-releasing peptide receptor (GRPR) is found to be overexpressed in a variety of
human tumors. The aim of this study was to develop 18F-labeled bombesin analogs for PET …

Dual-modality imaging of prostate cancer with a fluorescent and radiogallium-labeled gastrin-releasing peptide receptor antagonist

H Zhang, P Desai, Y Koike, J Houghton… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Gastrin-releasing peptide (GRP) receptors (GRPr) are frequently overexpressed in human
prostate cancer, and radiolabeled GRPr affinity ligands have shown promise for in vivo …

microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3] bombesin in human prostate adenocarcinoma xenografts

X Chen, R Park, Y Hou, M Tohme… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Overexpression of gastrin-releasing peptide (GRP) receptor (GRPR) in both androgen-
dependent (AD) and androgen-independent (AI) human neoplastic prostate tissues provides …