The term non-targeted metabolomics implies a global and unbiased analysis. This involves
the complex (and yet not routine) task of correct alignment and eventually annotation of …

Data analysis is a very challenging task in LC-MS metabolomic studies. The use of powerful
analytical techniques (eg, high-resolution mass spectrometry) provides high-dimensional …

Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Metabolomics aims at detection and quantitation of all metabolites in biological samples.
The presence of metabolites with a wide variety of physicochemical properties and different …

Targeted metabolomics has been broadly used for metabolite measurement due to its good
quantitative linearity and simple metabolite annotation workflow. However, metabolite …

The goal of metabolomics analyses is detection and quantitation of as many sample
components as reasonably possible in order to identify compounds or “features” that can be …

Metabolomics, the global study of small molecules in a particular system, has in the past few
years risen to become a primary-omics platform for the study of metabolic processes. With …

Liquid chromatography–mass spectrometry (LC–MS)-based untargeted metabolomics is
constantly challenged by large-scale and unambiguous metabolite annotation in complex …

Liquid chromatography coupled to tandem mass spectrometry is one of the most widely
used analytical platforms for profiling analysis in metabolomics. One weakness of …

Untargeted metabolomics using liquid chromatography–mass spectrometry (LC–MS) is
currently the gold-standard technique to determine the full chemical diversity in biological …