Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

CKDGen Consortium, KidneyGen Consortium… - Nature, 2011 - nature.com
Blood pressure is a heritable trait influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥ 140 mm …

Genomewide linkage scan of resting blood pressure: HERITAGE Family Study

T Rice, T Rankinen, YC Chagnon, MA Province… - …, 2002 - Am Heart Assoc
The purpose of this study was to search for genomic regions influencing resting systolic
(SBP) and diastolic (DBP) blood pressure (BP) in sedentary families (baseline), and for …

Genome scans for hypertension and blood pressure regulation

NJ Samani - American Journal of Hypertension, 2003 - academic.oup.com
Genome scans for hypertension and blood pressure regulation | American Journal of
Hypertension | Oxford Academic Skip to Main Content Advertisement Oxford Academic Journals …

Understanding the role of genetics in hypertension

RS Patel, S Masi, S Taddei - European heart journal, 2017 - academic.oup.com
Hypertension is a major modifiable risk factor for renal, cardiovascular, and cerebrovascular
disease, and a leading underlying cause of global mortality and morbidity. 1 Incremental …

A genome-wide association study of hypertension and blood pressure in African Americans

A Adeyemo, N Gerry, G Chen, A Herbert… - PLoS …, 2009 - journals.plos.org
The evidence for the existence of genetic susceptibility variants for the common form of
hypertension (“essential hypertension”) remains weak and inconsistent. We sought genetic …

Blood pressure loci identified with a gene-centric array

T Johnson, TR Gaunt, SJ Newhouse… - The American Journal of …, 2011 - cell.com
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous
studies have identified 47 distinct genetic variants robustly associated with BP, but …

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

N Kato, M Loh, F Takeuchi, N Verweij, X Wang… - Nature …, 2015 - nature.com
We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney

LV Wain, A Vaez, R Jansen, R Joehanes… - …, 2017 - Am Heart Assoc
Elevated blood pressure is a major risk factor for cardiovascular disease and has a
substantial genetic contribution. Genetic variation influencing blood pressure has the …

Evidence for a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the …

D Levy, AL DeStefano, MG Larson, CJ O'Donnell… - …, 2000 - Am Heart Assoc
Hypertension is a leading cause of morbidity and mortality. Efforts to identify hypertension
genes have focused on 3 approaches: mendelian disorders, candidate genes, and genome …

Lack of association of 3 functional gene variants with hypertension in African Americans

N Larson, R Hutchinson, E Boerwinkle - Hypertension, 2000 - Am Heart Assoc
African Americans are a critical population in which to study the impact of physiologically
important candidate gene mutations on the occurrence of hypertension. African Americans …