Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Key points The development of age‐related arterial endothelial dysfunction, a key
antecedent of increased cardiovascular disease (CVD) risk, is mediated largely by reduced …

Nutritional supplements, calorie restriction, and life style change are the most effective
preventive strategies to improve mitochondrial function and reduce mitochondrial oxidative …

Cardiovascular diseases (CVD) are the leading cause of death worldwide and aging is the
primary risk factor for CVD. The development of vascular dysfunction, including endothelial …

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries,
which causes claudication. This may be in part due to vascular mitochondrial dysfunction …

Aortic stiffening is a major independent risk factor for cardiovascular diseases, cognitive
dysfunction, and other chronic disorders of aging. Mitochondria-derived reactive oxygen …

Vascular mitochondria constantly integrate signals from environment and respond
accordingly to match vascular function to metabolic requirements of the organ tissues, while …

This review focuses on mitochondrial abnormalities that occur in the vasculature during
aging and explores the link between mitochondrial oxidative stress, chronic low-grade …

Mitochondria are a major site of reactive oxygen species production, which may contribute to
the development of cardiovascular disease. Protecting mitochondria from oxidative damage …

The heart is dependent on ATP production in mitochondria, which is closely associated with
cardiovascular disease because of the oxidative stress produced by mitochondria …