Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries

M Siermann, V van der Schoot, EM Bunnik… - Human …, 2024 - academic.oup.com
STUDY QUESTION Would the different regulatory approaches for preimplantation genetic
testing (PGT) in Europe permit the implementation of preimplantation genetic testing using …

Limitations, concerns and potential: attitudes of healthcare professionals toward preimplantation genetic testing using polygenic risk scores

M Siermann, O Valcke, JR Vermeesch… - European Journal of …, 2023 - nature.com
Preimplantation genetic testing using polygenic risk scores (PGT-P) has recently been
introduced. However, PGT-P has been met with many ethical concerns. It is therefore …

“Are we not going too far?“: Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals

M Siermann, O Valcke, JR Vermeesch, T Raivio… - Social Science & …, 2024 - Elsevier
The recent introduction of polygenic risk scores within preimplantation genetic testing (PGT-
P) has been met with many concerns. To get more insights into the perspectives of relevant …

[HTML][HTML] A review of normative documents on preimplantation genetic testing: recommendations for PGT-P

M Siermann, O Tšuiko, JR Vermeesch, T Raivio… - Genetics in …, 2022 - Elsevier
Purpose Recently, preimplantation genetic testing (PGT) for polygenic conditions (PGT-P)
has been introduced commercially. In view of the lack of specific guidance on this …

Perspectives of preimplantation genetic testing patients in Belgium on the ethics of polygenic embryo screening

M Siermann, JR Vermeesch, T Raivio, A Vanhie… - Reproductive …, 2024 - Elsevier
Research question What are the perspectives of preimplantation genetic testing (PGT)
patients in Belgium on the ethics of PGT for polygenic risk scoring (PGT-P)? Design In-depth …

Regulatory safeguards needed if preimplantation genetic testing for polygenic risk scores (PGT-P) is permitted in Singapore

AHB Chin, LW Lim, SM Muhsin - Journal of Medical Ethics, 2024 - jme.bmj.com
Singapore, a highly affluent island city-state located in Southeast Asia, has increasingly
leveraged new assisted reproductive technologies (ART) to overcome its dismal fertility rates …

Preimplantation genetic testing: comparative analysis of jurisprudential regulations

C Casella, L Carbone, A Conforti, V Marrone… - ITALIAN JOURNAL OF …, 2020 - iris.unina.it
Preimplantation genetic testing (PGT) is used to screen for genetic diseases or
chromosomal abnormalities in couples at risk of transmission to the offspring. It can be …

Preimplantation genetic testing for more than one genetic condition: clinical and ethical considerations and dilemmas

V Van der Schoot, W Dondorp, J Dreesen… - Human …, 2019 - academic.oup.com
STUDY QUESTION Which clinical and ethical aspects of preimplantation genetic testing for
monogenic disorders or structural rearrangements (PGT-M, PGT-SR) should be considered …

A systematic review of the views of healthcare professionals on the scope of preimplantation genetic testing

M Siermann, Z Claesen, L Pasquier, T Raivio… - Journal of Community …, 2022 - Springer
Preimplantation genetic testing (PGT) involves testing embryos created through in vitro
fertilization for the presence of hereditary genetic disorders and chromosome abnormalities …

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

F Forzano, O Antonova, A Clarke, G de Wert… - European Journal of …, 2022 - nature.com
Polygenic risk score analyses on embryos (PGT-P) are being marketed by some private
testing companies to parents using in vitro fertilisation as being useful in selecting the …