BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein
beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor …

In this study, we sought out to test the hypothesis that genetic factors may influence
antidepressant response to fluoxetine. The investigation focused on seven candidate genes …

Serotonin systems appear to play a key role in the pathogenesis of major depression and
the therapeutic mechanisms of antidepressants. The firing rate of dorsal raphe serotonergic …

Abstract Background and Objectives Several gene variants have been related to major
depressive disorder (MDD) treatment outcomes; however, few studies have investigated a …

The majority of antidepressant drugs act by increasing synaptic serotonin levels in the brain.
Genetic variation in serotonin-related genes may therefore influence antidepressant efficacy …

Objective This study investigates the relationship between the serotonin transporter linked
polymorphic region (5-HTTLPR) and the long-term outcome of antidepressant treatment …

Abstract The serotonin transporter (5-HTT) is the site of primary action for the selective
serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the …

Serotonergic pathways are known to play an essential role in the effects generated by
antidepressants. Polymorphisms in serotonin receptor and transporter genes have been …

Objective Several investigations have suggested that alterations in serotonin 6 (5‐HT6)
receptors might be associated with the pathophysiology of major depressive disorder …

Objectives To investigate whether the serotonin transporter (5-HTT or SERT or SLC6A4)
mRNA level could be used as a biomarker of treatment response in patients with major …