Abstract Background and Aim: Tumor–mesenchymal interactions are involved in the
mechanism of tumor invasion in several types of carcinoma. Mutual interactions between …

Emerging evidence has revealed that neutrophils have phenotypic and functional plasticity.
Neutrophils could be polarized towards a pro-tumor phenotype by tumor-derived factors. In …

Inflammation is a component of tumor progression mechanisms. Neutrophils are a common
inflammatory infiltrate in many tumors, but their regulation and functions in neoplasia are not …

Background Hepatocyte growth factor or scatter factor (HGF/SF) is a pleiotropic cytokine that
has potent angiogenic properties. We have previously demonstrated that neutrophils (PMN) …

Background Distant metastasis is a sign of poor prognosis for cancer patients. Extrahepatic
liver cancer metastases commonly spread to the lung. Remodelling of the metastatic …

We investigated whether hepatocyte growth factor (HGF) enhances the invasion activity of
three human HCC cell lines, HLF, HLE, and HC-4, in vitro. The analysis of the invasiveness …

AIM: Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic
biological effects on epithelial cells, such as proliferation, motogenesis, invas-iveness and …

Background & Aims Neutrophils are one of the most abundant components in human
hepatocellular carcinoma (HCC) and have been shown to play important roles in regulating …

Increased numbers of tumor-infiltrating neutrophils are linked to poorer outcome in patients
with adenocarcinoma of the bronchioloalveolar carcinoma (BAC) subtype. Hepatocyte …

BACKGROUND & AIMS: Neutrophil infiltration has been linked to clinical outcome of various
cancer types. However, its role in hepatocellular carcinoma (HCC) is unclear. In this study …