The NLRP3 inflammasome is an important component of the innate immune system.
However, its mechanism of activation remains largely unknown. We show that NLRP3 …

Recognition of microbe‐associated molecular patterns or endogenous danger signals by a
subset of cytosolic PRRs results in the assembly of multiprotein signaling complexes, the so …

Inflammasomes are high-molecular-weight protein complexes that are formed in the
cytosolic compartment in response to danger-or pathogen-associated molecular patterns …

Inflammasomes are Nod-like receptor (NLR)-and caspase-1-containing cytoplasmic
multiprotein complexes, which upon their assembly, process and activate the …

Highlights•NLRP3 is a sensor of dysregulated intracellular ion homeostasis.•Intracellular K+
depletion is common to canonical and non-canonical NLRP3 activation.•Cl− efflux is a …

The assembly of the NLRP3 inflammasome can promote the release of IL-1β/IL-18 and
initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation is …

The Nlrp3 inflammasome is critical for the activation of caspase-1 in response to danger
signals and particulate matter. However, its role in sterile inflammation remains unclear …

Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled
activation is associated with inflammatory disorders, suggesting that regulation of the …

Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the
maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly …

Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-
binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was …