BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are
associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we …

Variation in serum bilirubin is associated with altered cardiovascular disease risk and drug
metabolism. We aimed to identify genetic contributors to variability in serum bilirubin levels …

Background & Aims A genome-wide association study (GWAS) of 280 cases identified the
hepatic cholesterol transporter ABCG8 as a locus associated with risk for gallstone disease …

The major enzyme responsible for the glucuronidation of bilirubin is the uridine 5′-
diphosphoglucose glucuronosyltransferase A1 (UGT1A1) enzyme, and genetic variation in …

A large-scale, genome-wide association study was performed to identify genetic variations
influencing serum bilirubin levels using 8841 Korean individuals. Significant associations …

Gallstone disease is a common complex disease that confers a substantial economic
burden on society. The genetic underpinnings of gallstone disease remain incompletely …

Gallstones are responsible for one of the most common diseases in the Western world and
are commonly treated with cholecystectomy. We perform a meta-analysis of two genome …

Total serum bilirubin is associated with several clinical outcomes, including cardiovascular
disease, diabetes and drug metabolism. We conducted a genome-wide association study in …

Importance In individuals without blockage of their bile ducts, levels of plasma bilirubin likely
reflect levels of biliary bilirubin; higher biliary bilirubin levels may increase the risk of …

Bilirubin is an effective antioxidant and is influenced by both genetic and environmental
factors. Recent genome‐wide association studies (GWAS) have identified multiple loci …