Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron

ML Hammarskjöld, H Li, D Rekosh, S Prasad - Journal of virology, 1994 - Am Soc Microbiol
The human immunodeficiency virus (HIV) Rev protein functions to facilitate export of intron-
containing HIV mRNA from the nucleus to the cytoplasm. We have previously shown that …

Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA

G Nasioulas, AS Zolotukhin, C Tabernero… - Journal of …, 1994 - Am Soc Microbiol
In the absence of the viral regulatory protein Rev, the human immunodeficiency virus type 1
gag/pol and env mRNAs are inefficiently expressed, since nucleocytoplasmic transport …

Regulation of human immunodeficiency virus env expression by the rev gene product

ML Hammarskjöld, J Heimer, B Hammarskjöld… - Journal of …, 1989 - Am Soc Microbiol
A single simian virus 40 late replacement vector which expresses both the rev and envelope
(env) genes of human immunodeficiency virus was used to examine the mechanism …

Positive and Negative Modulation of Human Immunodeficiency Virus Type 1 Rev Function by cis and trans Regulators of Viral RNA Splicing

J Pongoski, K Asai, A Cochrane - Journal of virology, 2002 - Am Soc Microbiol
Expression of the entire complement of human immunodeficiency virus type 1 (HIV-1) viral
proteins depends on the competing activities of viral RNA splicing and export into the …

Regulation by HIV Rev depends upon recognition of splice sites

DD Chang, PA Sharp - Cell, 1989 - cell.com
The ability of the Rev protein of HIV to regulate the cytoplasmic level of unspliced RNA from
a P-globin gene containing the Rev response element was dependent on the integrity of the …

The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6. U5 small nuclear ribonucleoprotein in spliceosome …

J Kjems, PA Sharp - Journal of virology, 1993 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) encodes a regulatory protein, Rev, which is
required for cytoplasmic expression of incompletely spliced viral mRNA. Rev binds to a cis …

A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs …

DW Brighty, M Rosenberg - Proceedings of the National …, 1994 - National Acad Sciences
The Rev protein of human immunodeficiency virus type 1 (HIV-1) binds to an RNA structure,
the Rev-responsive element (RRE), to enhance expression of the viral structural genes by …

Effect of rev on the cytoplasmic localization of intron-containing human immunodeficiency virus type 1 RNA

JP Favaro, F Maldarelli, SJ Arrigo, MG Schmidt - Virology, 1999 - Elsevier
Human immunodeficiency virus type 1 (HIV-1) proteins are expressed from both intron-
containing and completely spliced RNAs. Rev, an HIV-1 regulatory protein, is necessary for …

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

AW Cochrane, CH Chen… - Proceedings of the …, 1990 - National Acad Sciences
A region of potential complex secondary structure within the human immunodeficiency virus
env mRNA has been implicated in Rev-mediated export of viral structural mRNAs from the …

The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments

KH Kalland, AM Szilvay, KA Brokstad… - … and cellular biology, 1994 - Taylor & Francis
A retroviral regulatory protein, Rev (regulator of virion protein expression), is made in cells
infected by human immunodeficiency virus (HIV). Rev is essential for the completion of the …