To obtain region-and disease-specific transcription profiles of human myocardial tissue, we
explored mRNA expression from all four chambers of eight explanted failing [idiopathic …

Heart failure is a multifactorial disease that may result from different initiating events. To
contribute to an improved comprehension of normal cardiac function and the molecular …

Background: The objective of the present study was to use gene expression profiling,
functional annotations and classification to identify aetiology‐specific biological processes …

With the emergence of microarray technology, it is now possible to simultaneously assess
the expression of tens of thousands of gene transcripts, providing a resolution and precision …

Multiple pathways are responsible for transducing mechanical and hormonal stimuli into
changes in gene expression during heart failure. In this study our goals were (i) to develop a …

Traditional gene expression studies typically focus on one or a few genes of interest. An
important limitation of single-gene studies is that they present a portrait of disease that is …

Dilated cardiomyopathy is now the leading cause of cardiovascular morbidity and mortality.
While the molecular basis of this disease remains uncertain, evidence is emerging that gene …

OBJECTIVES: The knowledge of chamber-specific gene expression in human atrial and
ventricular myocardium is essential for the understanding of myocardial function and the …

Our understanding of the cardiovascular system has evolved through the years by extensive
studies emphasizing the identification of the molecular and physiological mechanisms …

Heart failure (HF) is the end result of progressive and diverse biological adaptations within
the diseased myocardium. We used cDNA microarrays and quantitative PCR to examine the …