Toll-like receptors (TLRs) form a family of pattern recognition receptors with at least 11
members in human and 13 in mouse. TLRs recognize a wide variety of putative host-derived …

Introduction• TLR signalling• Endogenous TLR ligands• Biological significance of signalling
triggered by endogenous TLR ligands‐Ischemia and reperfusion injury‐Tissue repair and …

Toll-like receptors (TLRs) form a large family of pattern recognition receptors with at least 11
members in human and 13 in mouse. TLRs recognize a wide variety of microbial …

Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …

The family of Toll-like receptors (TLR1-TLR11) provides host defense in mammals by
inducing proinflammatory innate immune response upon recognition of conserved structural …

Abstract Human Toll-like receptors (TLRs) are a family of transmembrane receptors, which
play a key role in both innate and adaptive immune responses. Beside of recognizing …

Inflammation is set off when innate immune cells detect infection or tissue injury. Tight
control of the severity, duration, and location of inflammation is an absolute requirement for …

The outcome of sepsis and septic shock has not significantly improved in recent decades
despite the development of numerous drugs and supportive care therapies. To reduce …

Following injury a complex but well-orchestrated cellular response stimulating wound
healing and tissue regeneration is induced. The balance of different cytokines, growth …

There is a permanent interaction amid the innate and adaptive immune systems that leads to
a defensive immune response against pathogens and contributes substantially to self …