Ctip1 regulates the balance between specification of distinct projection neuron subtypes in deep cortical layers
The molecular linkage between neocortical projection neuron subtype and area
development, which enables the establishment of functional areas by projection neuron …
development, which enables the establishment of functional areas by projection neuron …
Ctip1 controls acquisition of sensory area identity and establishment of sensory input fields in the developing neocortex
LC Greig, MB Woodworth, C Greppi, JD Macklis - Neuron, 2016 - cell.com
While transcriptional controls over the size and relative position of cortical areas have been
identified, less is known about regulators that direct acquisition of area-specific …
identified, less is known about regulators that direct acquisition of area-specific …
Area-specific development of distinct projection neuron subclasses is regulated by postnatal epigenetic modifications
K Harb, E Magrinelli, CS Nicolas, N Lukianets… - Elife, 2016 - elifesciences.org
During cortical development, the identity of major classes of long-distance projection
neurons is established by the expression of molecular determinants, which become …
neurons is established by the expression of molecular determinants, which become …
The specification of cortical subcerebral projection neurons depends on the direct repression of TBR1 by CTIP1/BCL11a
J Cánovas, FA Berndt, H Sepúlveda… - Journal of …, 2015 - Soc Neuroscience
The acquisition of distinct neuronal fates is fundamental for the function of the cerebral
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation
S Srivatsa, S Parthasarathy, O Britanova… - Nature …, 2014 - nature.com
The pyramidal neurons of the mammalian neocortex form two major types of long-range
connections—corticocortical and cortico-subcortical. The transcription factors Satb2 and …
connections—corticocortical and cortico-subcortical. The transcription factors Satb2 and …
The determination of projection neuron identity in the developing cerebral cortex
DP Leone, K Srinivasan, B Chen, E Alcamo… - Current opinion in …, 2008 - Elsevier
Here we review the mechanisms that determine projection neuron identity during cortical
development. Pyramidal neurons in the mammalian cerebral cortex can be classified into …
development. Pyramidal neurons in the mammalian cerebral cortex can be classified into …
A network of genetic repression and derepression specifies projection fates in the developing neocortex
K Srinivasan, DP Leone, RK Bateson… - Proceedings of the …, 2012 - National Acad Sciences
Neurons within each layer in the mammalian cortex have stereotypic projections. Four
genes—Fezf2, Ctip2, Tbr1, and Satb2—regulate these projection identities. These genes …
genes—Fezf2, Ctip2, Tbr1, and Satb2—regulate these projection identities. These genes …
Differential timing of a conserved transcriptional network underlies divergent cortical projection routes across mammalian brain evolution
A unique combination of transcription factor expression and projection neuron identity
demarcates each layer of the cerebral cortex. During mouse and human cortical …
demarcates each layer of the cerebral cortex. During mouse and human cortical …
Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c
C Wiegreffe, R Simon, K Peschkes, C Kling, M Strehle… - Neuron, 2015 - cell.com
During neocortical development, neurons undergo polarization, oriented migration, and
layer-type-specific differentiation. The transcriptional programs underlying these processes …
layer-type-specific differentiation. The transcriptional programs underlying these processes …
The Fezf2–Ctip2 genetic pathway regulates the fate choice of subcortical projection neurons in the developing cerebral cortex
B Chen, SS Wang, AM Hattox… - Proceedings of the …, 2008 - National Acad Sciences
Pyramidal neurons in the deep layers of the cerebral cortex can be classified into two major
classes: callosal projection neurons and long-range subcortical neurons. We and others …
classes: callosal projection neurons and long-range subcortical neurons. We and others …